Please use this identifier to cite or link to this item: https://hdl.handle.net/10137/12539
Title: Pericoronary adipose tissue attenuation on coronary computed tomography angiography associates with male sex and Indigenous Australian status.
Authors: Yuvaraj J
Lim E
Vo T
Huynh D
Rocco C
Nerlekar N
Cheng K
Lin A
Dey D
Nicholls S J
Kangaharan N
Wong D T L
Citation: © 2023. Springer Nature Limited.
Sci Rep. 2023 Sep 19;13(1):15509. doi: 10.1038/s41598-023-41341-9.
Abstract: To evaluate if Indigenous Australians have higher coronary inflammation demonstrated non-invasively using pericoronary adipose tissue attenuation on coronary computed tomography angiography (CCTA). We retrospectively obtained a cohort 54 Indigenous patients age- and sex-matched to 54 non-Indigenous controls (age: 46.5 ± 13.1 years; male: n = 66) undergoing CCTA at the Royal Darwin Hospital and Monash Medical Centre. Patient groups were defined to investigate the interaction of ethnicity and sex: Indigenous + male, Indigenous + female, control + male, control + female. Semi-automated software was used to assess pericoronary adipose tissue attenuation (PCAT-a) and volume (PCAT-v). Males had significantly higher PCAT-a (- 86.7 ± 7.8 HU vs. - 91.3 ± 7.1 HU, p = 0.003) than females. Indigenous patients had significantly higher PCAT-v (1.5 ± 0.5cm(3) vs. 1.3 ± 0.4cm(3), p = 0.032), but only numerically higher PCAT-a (p = 0.133) than controls. There was a significant difference in PCAT-a and PCAT-v across groups defined by Indigenous status and sex (p = 0.010 and p = 0.030, respectively). Among patients with matching CCTA contrast density, multivariable linear regression analysis showed an independent association between Indigenous status and PCAT-a. Indigenous men have increased PCAT-a in an age- and sex-matched cohort. Male sex is strongly associated with increased PCAT-a. Coronary inflammation may contribute to adverse cardiovascular outcomes in Indigenous Australians, but larger studies are required to validate these findings.
Click to open Pubmed Article: https://www.ezpdhcs.nt.gov.au/login?url=https://www.ncbi.nlm.nih.gov/pubmed/37726291
Journal title: Scientific reports
Volume: 13
Pages: 15509
Publication Date: 2023-09-19
Type: Journal Article
URI: https://hdl.handle.net/10137/12539
DOI: 10.1038/s41598-023-41341-9
15509
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