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Title: Broad spectrum SARS-CoV-2-specific immunity in hospitalized First Nations peoples recovering from COVID-19.
Authors: Zhang W
Clemens E B
Kedzierski L
Chua B Y
Mayo M
Lonzi C
Hinchcliff A
Rigas V
Middleton B F
Binks P
Rowntree L C
Allen L F
Tan H-X
Petersen J
Chaurasia P
Krammer F
Wheatley A K
Kent S J
Rossjohn J
Miller A
Lynar S
Nelson J
Nguyen T H
Davies J
Kedzierska K
Citation: © 2023 The Authors. Immunology & Cell Biology published by John Wiley & Sons Australia, Ltd on behalf of the Australian and New Zealand Society for Immunology, Inc.
Immunol Cell Biol. 2023 Sep 19. doi: 10.1111/imcb.12691.
Abstract: Indigenous peoples globally are at increased risk of COVID-19-associated morbidity and mortality. However, data that describe immune responses to SARS-CoV-2 infection in Indigenous populations are lacking. We evaluated immune responses in Australian First Nations peoples hospitalized with COVID-19. Our work comprehensively mapped out inflammatory, humoral and adaptive immune responses following SARS-CoV-2 infection. Patients were recruited early following the lifting of strict public health measures in the Northern Territory, Australia, between November 2021 and May 2022. Australian First Nations peoples recovering from COVID-19 showed increased levels of MCP-1 and IL-8 cytokines, IgG-antibodies against Delta-RBD and memory SARS-CoV-2-specific T cell responses prior to hospital discharge in comparison with hospital admission, with resolution of hyperactivated HLA-DR(+) CD38(+) T cells. SARS-CoV-2 infection elicited coordinated ASC, Tfh and CD8(+) T cell responses in concert with CD4(+) T cell responses. Delta and Omicron RBD-IgG, as well as Ancestral N-IgG antibodies, strongly correlated with Ancestral RBD-IgG antibodies and Spike-specific memory B cells. We provide evidence of broad and robust immune responses following SARS-CoV-2 infection in Indigenous peoples, resembling those of non-Indigenous COVID-19 hospitalized patients.
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Journal title: Immunology and cell biology
Publication Date: 2023-09-19
Type: Journal Article
DOI: 10.1111/imcb.12691
Orcid: 0000-0001-7460-4956
Appears in Collections:(a) NT Health Research Collection

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