Please use this identifier to cite or link to this item:
Full metadata record
DC FieldValueLanguage
dc.contributor.authorTitmuss A-
dc.contributor.authorBarzi F-
dc.contributor.authorBarr E L M-
dc.contributor.authorWebster V-
dc.contributor.authorWood A-
dc.contributor.authorKelaart J-
dc.contributor.authorKirkwood M-
dc.contributor.authorConnors C-
dc.contributor.authorBoyle J A-
dc.contributor.authorMoore E-
dc.contributor.authorOats J-
dc.contributor.authorMcIntyre H D-
dc.contributor.authorZimmet P-
dc.contributor.authorBrown A D H-
dc.contributor.authorShaw J E-
dc.contributor.authorCraig M E-
dc.contributor.authorMaple-Brown L J-
dc.identifier.citation© 2023. The Author(s).-
dc.identifier.citationInt J Obes (Lond). 2023 Aug 22. doi: 10.1038/s41366-023-01366-6.-
dc.description.abstractBACKGROUND: In-utero hyperglycemia exposure influences later cardiometabolic risk, although few studies include women with pre-existing type 2 diabetes (T2D) or assess maternal body mass index (BMI) as a potential confounder. OBJECTIVE: To explore the association of maternal T2D and gestational diabetes mellitus (GDM) with childhood anthropometry, and the influence of maternal BMI on these associations. METHODS: The PANDORA cohort comprises women (n = 1138) and children (n = 1163). Women with GDM and T2D were recruited from a hyperglycemia in pregnancy register, and women with normoglycemia from the community. Wave 1 follow-up included 423 children, aged 1.5-5 years (median follow-up age 2.5 years). Multivariable linear regression assessed associations between maternal antenatal variables, including BMI and glycemic status, with offspring anthropometry (weight, height, BMI, skinfold thicknesses, waist, arm and head circumferences). RESULTS: Greater maternal antenatal BMI was associated with increased anthropometric measures in offspring independent of maternal glycemic status. After adjustment, including for maternal BMI, children exposed to maternal GDM had lower mean weight (-0.54 kg, 95% CI: -0.99, -0.11), BMI (-0.55 kg/m(2), 95% CI: -0.91, -0.20), head (-0.52 cm, 95% CI: -0.88, -0.16) and mid-upper arm (-0.32 cm, 95% CI: -0.63, -0.01) circumferences, and greater mean suprailiac skinfold (0.78 mm, 95% CI: 0.13, 1.43), compared to children exposed to normoglycemia. Adjustment for maternal BMI strengthened the negative association between GDM and child weight, BMI and circumferences. Children exposed to maternal T2D had smaller mean head circumference (-0.82 cm, 95% CI: -1.33, -0.31) than children exposed to normoglycemia. Maternal T2D was no longer associated with greater child mean skinfolds (p = 0.14) or waist circumference (p = 0.18) after adjustment for maternal BMI. CONCLUSIONS: Children exposed to GDM had greater suprailiac skinfold thickness than unexposed children, despite having lower mean weight, BMI and mid-upper arm circumference, and both GDM and T2D were associated with smaller mean head circumference. Future research should assess whether childhood anthropometric differences influence lifetime cardiometabolic and neurodevelopmental risk.-
dc.titleAssociation between maternal hyperglycemia in pregnancy and offspring anthropometry in early childhood: the pandora wave 1 study.-
dc.typeJournal Article-
dc.identifier.journaltitleInternational journal of obesity (2005)-
dc.description.affiliationWellbeing and Preventable Chronic Diseases Division, Menzies School of Health Research, Charles Darwin University, Darwin, NT, Australia.
dc.description.affiliationPaediatric Department, Division of Women, Child and Youth, Royal Darwin Hospital, Darwin, NT, Australia.
dc.description.affiliationWellbeing and Preventable Chronic Diseases Division, Menzies School of Health Research, Charles Darwin University, Darwin, NT, Australia.-
dc.description.affiliationPoche Centre for Indigenous Health, University of Queensland, Brisbane, QLD, Australia.-
dc.description.affiliationClinical and Population Health, Baker Heart and Diabetes Institute, Melbourne, VIC, Australia.-
dc.description.affiliationEndocrinology Department, Division of Medicine, Royal Darwin Hospital, Darwin, NT, Australia.-
dc.description.affiliationAboriginal Health Domain, Baker Heart and Diabetes Institute, Alice Springs, NT, Australia.-
dc.description.affiliationNorthern Territory Department of Health, Darwin, NT, Australia.-
dc.description.affiliationMonash Centre for Health Research and Implementation, School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia.-
dc.description.affiliationPublic Health Unit, Aboriginal Medical Services Alliance of Northern Territory, Darwin, NT, Australia.-
dc.description.affiliationMelbourne School of Population and Global Health, University of Melbourne, Melbourne, VIC, Australia.-
dc.description.affiliationFaculty of Medicine, Mater Medical Research Institute, University of Queensland, Brisbane, QLD, Australia.-
dc.description.affiliationDepartment of Diabetes, Central Clinical School, Monash University, Melbourne, VIC, Australia.-
dc.description.affiliationUniversity of South Australia, Adelaide, SA, Australia.-
dc.description.affiliationWardliparingga Aboriginal Research Unit, South Australian Health and Medical Research Institute, Adelaide, SA, Australia.-
dc.description.affiliationAustralian National University, Canberra, ACT, Australia.-
dc.description.affiliationTelethon Kids Institute, Perth, WA, Australia.-
dc.description.affiliationSchool of Women's and Children's Health, University of New South Wales, Sydney, NSW, Australia.-
local.issue.number1476-5497 (Electronic)-
local.issue.number0307-0565 (Linking)-
Appears in Collections:(a) NT Health Research Collection

Files in This Item:
There are no files associated with this item.

Items in ePublications are protected by copyright, with all rights reserved, unless otherwise indicated.

Google Media

Google ScholarTM

Who's citing


PubMed References

Who's citing