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Title: Fetal sex and risk of pregnancy-associated malaria in Plasmodium falciparum-endemic regions: a meta-analysis.
Authors: Unger, Holger W
Hadiprodjo, Anastasia Jessica
Gutman, Julie R
Briand, Valerie
Fievet, Nadine
Valea, Innocent
Tinto, Halidou
D'Alessandro, Umberto
Landis, Sarah H
Ter Kuile, Feiko
Ouma, Peter
Oneko, Martina
Mwapasa, Victor
Slutsker, Laurence
Terlouw, Dianne J
Kariuki, Simon
Ayisi, John
Nahlen, Bernard
Desai, Meghna
Madanitsa, Mwayi
Kalilani-Phiri, Linda
Ashorn, Per
Maleta, Kenneth
Tshefu-Kitoto, Antoinette
Mueller, Ivo
Stanisic, Danielle
Cates, Jordan
Van Eijk, Anna Maria
Ome-Kaius, Maria
Aitken, Elizabeth H
Rogerson, Stephen J
Citation: © 2023. The Author(s).
Sci Rep. 2023 Jun 26;13(1):10310. doi: 10.1038/s41598-023-37431-3.
Abstract: In areas of moderate to intense Plasmodium falciparum transmission, malaria in pregnancy remains a significant cause of low birth weight, stillbirth, and severe anaemia. Previously, fetal sex has been identified to modify the risks of maternal asthma, pre-eclampsia, and gestational diabetes. One study demonstrated increased risk of placental malaria in women carrying a female fetus. We investigated the association between fetal sex and malaria in pregnancy in 11 pregnancy studies conducted in sub-Saharan African countries and Papua New Guinea through meta-analysis using log binomial regression fitted to a random-effects model. Malaria infection during pregnancy and delivery was assessed using light microscopy, polymerase chain reaction, and histology. Five studies were observational studies and six were randomised controlled trials. Studies varied in terms of gravidity, gestational age at antenatal enrolment and bed net use. Presence of a female fetus was associated with malaria infection at enrolment by light microscopy (risk ratio 1.14 [95% confidence interval 1.04, 1.24]; P = 0.003; n = 11,729). Fetal sex did not associate with malaria infection when other time points or diagnostic methods were used. There is limited evidence that fetal sex influences the risk of malaria infection in pregnancy.
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Journal title: Scientific reports
Volume: 13
Pages: 10310
Publication Date: 2023
Type: Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
DOI: 10.1038/s41598-023-37431-3
Appears in Collections:(a) NT Health Research Collection

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