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dc.contributor.authorMeumann EMen
dc.contributor.authorHoran Ken
dc.contributor.authorRalph APen
dc.contributor.authorFarmer Ben
dc.contributor.authorGloban Men
dc.contributor.authorStephenson Een
dc.contributor.authorPopple Ten
dc.contributor.authorBoyd Ren
dc.contributor.authorKaestli Men
dc.contributor.authorSeemann Ten
dc.contributor.authorVandelannoote Ken
dc.contributor.authorLowbridge Cen
dc.contributor.authorBaird RWen
dc.contributor.authorStinear TPen
dc.contributor.authorWilliamson DAen
dc.contributor.authorCurrie BJen
dc.contributor.authorKrause VLen
dc.identifier.citation© 2021 The Authors.en
dc.identifier.citationLancet Reg Health West Pac. 2021 Jul 31;15:100229. doi: 10.1016/j.lanwpc.2021.100229. eCollection 2021 Oct.en
dc.description.abstractBACKGROUND: The Northern Territory (NT) has the highest tuberculosis (TB) rate of all Australian jurisdictions. We combined TB public health surveillance data with genomic sequencing of Mycobacterium tuberculosis isolates in the tropical 'Top End' of the NT to investigate trends in TB incidence and transmission. METHODS: This retrospective observational study included all 741 culture-confirmed cases of TB in the Top End over three decades from 1989-2020. All 497 available M. tuberculosis isolates were sequenced. We used contact tracing data to define a threshold pairwise SNP distance for hierarchical single linkage clustering, and examined putative transmission clusters in the context of epidemiologic information. FINDINGS: There were 359 (48%) cases born overseas, 329 (44%) cases among Australian First Nations peoples, and 52 (7%) cases were Australian-born and non-Indigenous. The annual incidence in First Nations peoples from 1989-2019 fell from average 50.4 to 11.0 per 100,000 (P<0·001). First Nations cases were more likely to die from TB (41/329, 12·5%) than overseas-born cases (11/359, 3·1%; P<0·001). Using a threshold of ≤12 SNPs, 28 clusters of between 2-64 individuals were identified, totalling 250 cases; 214 (86%) were First Nations cases and 189 (76%) were from a remote region. The time between cases and past epidemiologically- and genomically-linked contacts ranged from 4·5 months to 24 years. INTERPRETATION: Our findings support prioritisation of timely case detection, contact tracing augmented by genomic sequencing, and latent TB treatment to break transmission chains in Top End remote hotspot regions.en
dc.titleTuberculosis in Australia's tropical north: a population-based genomic epidemiological study.en
dc.typeJournal Articleen
dc.identifier.journaltitleThe Lancet regional health. Western Pacificen
dc.description.affiliationGlobal and Tropical Health Division, Menzies School of Health Research, Charles Darwin University, Darwin, Australia.en
dc.description.affiliationDepartment of Infectious Diseases, Division of Medicine, Royal Darwin Hospital, Darwin, Australia.en
dc.description.affiliationTerritory Pathology, Royal Darwin Hospital, Darwin, Australia.en
dc.description.affiliationNothern Territory Centre for Disease Control, Northern Territory Government, Darwin, Australia.en
dc.description.affiliationMicrobiological Diagnostic Unit Public Health Laboratory, Department of Microbiology and Immunology, The University of Melbourne at The Peter Doherty Institute for Infection and Immunity, Melbourne, Australia.en
dc.description.affiliationMycobacterium Reference Laboratory, Victorian Infectious Diseases Reference Laboratory, Royal Melbourne Hospital at The Peter Doherty Institute for Infection and Immunity, Melbourne, Australia.en
dc.description.affiliationDepartment of Microbiology and Immunology, The University of Melbourne at The Peter Doherty Institute for Infection and Immunity, Melbourne, Australia.en
local.issue.number2666-6065 (Electronic)-
local.issue.number2666-6065 (Linking)-
Appears in Collections:(a) NT Health Research Collection

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