Please use this identifier to cite or link to this item: https://hdl.handle.net/10137/11856
Title: The role of Kingella kingae in pre-school aged children with bone and joint infections.
Authors: Olijve, Laudi
Amarasena, Lahiru
Best, Emma
Blyth, Christopher
van den Boom, Mirjam
Bowen, Asha
Bryant, Penelope A
Buttery, Jim
Dobinson, Hazel C
Davis, Joshua
Francis, Joshua
Goldsmith, Heidi
Griffiths, Elle
Hung, Te-Yu
Huynh, Julie
Kesson, Alison
Meehan, Andrea
McMullan, Brendan
Nourse, Clare
Palasanthiran, Pamela
Penumarthy, Rushi
Pilkington, Katie
Searle, Janine
Stephenson, Anya
Webb, Rachel
Williman, Jonathan
Walls, Tony
Citation: Copyright © 2021. Published by Elsevier Ltd.
J Infect. 2021 Sep;83(3):321-331. doi: 10.1016/j.jinf.2021.06.028. Epub 2021 Jul 12.
Abstract: OBJECTIVES: The Pre-school Osteoarticular Infection (POI) study aimed to describe the burden of disease, epidemiology, microbiology and treatment of acute osteoarticular infections (OAI) and the role of Kingella kingae in these infections. METHODS: Information about children 3-60 months of age who were hospitalized with an OAI to 11 different hospitals across Australia and New Zealand between January 2012 and December 2016 was collected retrospectively. RESULTS: A total of 907 cases (73%) were included. Blood cultures grew a likely pathogen in only 18% (140/781). The peak age of presentation was 12 to 24 months (466/907, 51%) and Kingella kingae was the most frequently detected microorganism in this age group (60/466, 13%). In the majority of cases, no microorganism was detected (517/907, 57%). Addition of PCR to culture increased detection rates of K. kingae. However, PCR was performed infrequently (63/907, 7%). CONCLUSIONS: This large multi-national study highlights the need for more widespread use of molecular diagnostic techniques for accurate microbiological diagnosis of OAI in pre-school aged children. The data from this study supports the hypothesis that a substantial proportion of pre-school aged children with OAI and no organism identified may in fact have undiagnosed K. kingae infection. Improved detection of Kingella cases is likely to reduce the average length of antimicrobial treatment.
Click to open Pubmed Article: https://www.ezpdhcs.nt.gov.au/login?url=https://www.ncbi.nlm.nih.gov/pubmed/34265316
Journal title: The Journal of infection
Volume: 83
Pages: 321-331
Publication Date: 2021-09
Type: Journal Article
URI: https://hdl.handle.net/10137/11856
DOI: 10.1016/j.jinf.2021.06.028
Appears in Collections:(a) NT Health Research Collection

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