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Title: Conservation of resistance nodulation cell division efflux pump mediated antibiotic resistance in Burkholderia cepacia complex and Burkholderia pseudomallei complex species.
Authors: Somprasong, Nawarat
Yi, Jinhee
Hall, Carina M
Webb, Jessica R
Sahl, Jason W
Wagner, David M
Keim, Paul
Currie, Bart J
Schweizer, Herbert P
Citation: Antimicrob Agents Chemother. 2021 Jun 28:AAC0092021. doi: 10.1128/AAC.00920-21.
Abstract: Burkholderia cepacia complex (Bcc) and Burkholderia pseudomallei complex (Bpc) species include pathogens that are typically multidrug resistant. Dominant intrinsic and acquired multidrug resistance mechanisms are efflux mediated by pumps of the resistance nodulation cell division (RND) family. From comparative bioinformatic and, in many instances, functional studies we infer that RND pump-based resistance mechanisms are conserved in Burkholderia. We propose to use these findings as a foundation for adoption of a uniform RND efflux pump nomenclature.
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Journal title: Antimicrobial agents and chemotherapy
Pages: AAC0092021
Publication Date: 2021-06-28
Type: Journal Article
DOI: 10.1128/AAC.00920-21
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