Please use this identifier to cite or link to this item: https://hdl.handle.net/10137/11803
Title: Feasibility of once weekly exenatide-LAR and enhanced diabetes care in Indigenous Australians with type 2 diabetes. (Long-acting-Once-Weekly-Exenatide laR-SUGAR, "Lower SUGAR" study).
Authors: Ekinci, Elif I
Pyrlis, Felicity
Hachem, Mariam
Maple-Brown, Louise
Brown, Alex
Maguire, Graeme
Churilov, Leonid
Cohen, Neale
Citation: This article is protected by copyright. All rights reserved.
Intern Med J. 2021 Jun 18. doi: 10.1111/imj.15428.
Abstract: AIMS: To assess the feasibility and metabolic effects of once weekly supervised injection of exenatide-LAR in addition to standard care in Indigenous Australians with type 2 diabetes. METHODS: Two communities in Central Australia with longstanding specialist clinical outreach services were allocated by random coin toss to receive once-weekly exenatide-LAR injection with weekly nurse review and adjustment of medication for 20 weeks (community with exenatide-LAR) or to weekly nurse review in addition to standard care over 20 weeks (community without exenatide-LAR). The primary outcome was the feasibility of the intensive diabetes management model of care with and without weekly supervised exenatide-LAR. Secondary outcomes included change in HbA1c. RESULTS: 13 participants from community with exenatide-LAR and 9 participants from the community without exenatide-LAR were analysed. 85% of individuals in the community with exenatide-LAR and 67% in the community without exenatide-LAR attended more than half of clinic visits. Median difference in the change in HbA1c from baseline to final visit, adjusted for baseline HbA1c, between the community with exenatide-LAR and the community without exenatide-LAR was -3.1%, 95% CI (-5.80%, -0.38%; p = 0.03). CONCLUSIONS: Weekly exenatide-LAR combined with weekly nurse review demonstrated greater improvements in HbA1c, highlighting its potential for use in remote communities. This article is protected by copyright. All rights reserved.
Click to open Pubmed Article: https://pubmed-ncbi-nlm-nih-gov.www.ezpdhcs.nt.gov.au/34142743/
Journal title: Internal medicine journal
Publication Date: 2021-06-18
Type: Journal Article
URI: https://hdl.handle.net/10137/11803
DOI: 10.1111/imj.15428
Orcid: 0000-0003-2372-395X
Appears in Collections:(a) NT Health Research Collection

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