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https://hdl.handle.net/10137/11732
Title: | Bilateral facial nerve palsy associated with amphiphysin antibody in metastatic breast cancer: a case report. |
Authors: | Kwatra, Vineet Charakidis, Michail Karanth, Narayan V |
Citation: | J Med Case Rep. 2021 Mar 26;15(1):158. doi: 10.1186/s13256-021-02727-3. |
Abstract: | BACKGROUND: Paraneoplastic neurological syndrome is an immune-mediated phenomenon where antibodies from tumor cells are produced against neuronal proteins. Amphiphysin antibody is an onconeural antibody linked to the diagnosis of breast cancer and small-cell lung cancer. It is uncommon and typically associated with stiff-person syndrome, of which 90% of patients are eventually diagnosed with breast cancer. CASE PRESENTATION: We present a case of a 47-year-old Caucasian woman with metastatic hormone receptor-positive breast cancer who developed bilateral facial nerve palsy while on treatment with nab-paclitaxel. The patient was found to have anti-amphiphysin antibody in the serum and cerebrospinal fluid. She was treated with methylprednisolone and intravenous immunoglobulin, which resulted in partial improvement in her facial nerve palsy. CONCLUSIONS: This case highlights a rare presentation of bilateral facial nerve palsy that likely related to paraneoplastic syndrome associated with the presence of anti-amphiphysin antibody. |
Click to open Pubmed Article: | https://www.ezpdhcs.nt.gov.au/login?url=https://www.ncbi.nlm.nih.gov/pubmed/33766120 |
Journal title: | Journal of medical case reports |
Volume: | 15 |
Pages: | 158 |
Publication Date: | 2021-03-26 |
Type: | Journal Article |
URI: | https://hdl.handle.net/10137/11732 |
DOI: | 10.1186/s13256-021-02727-3 158 |
Orcid: | 0000-0002-0912-4056 |
Appears in Collections: | (a) NT Health Research Collection |
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