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Title: Bilateral facial nerve palsy associated with amphiphysin antibody in metastatic breast cancer: a case report.
Authors: Kwatra, Vineet
Charakidis, Michail
Karanth, Narayan V
Citation: J Med Case Rep. 2021 Mar 26;15(1):158. doi: 10.1186/s13256-021-02727-3.
Abstract: BACKGROUND: Paraneoplastic neurological syndrome is an immune-mediated phenomenon where antibodies from tumor cells are produced against neuronal proteins. Amphiphysin antibody is an onconeural antibody linked to the diagnosis of breast cancer and small-cell lung cancer. It is uncommon and typically associated with stiff-person syndrome, of which 90% of patients are eventually diagnosed with breast cancer. CASE PRESENTATION: We present a case of a 47-year-old Caucasian woman with metastatic hormone receptor-positive breast cancer who developed bilateral facial nerve palsy while on treatment with nab-paclitaxel. The patient was found to have anti-amphiphysin antibody in the serum and cerebrospinal fluid. She was treated with methylprednisolone and intravenous immunoglobulin, which resulted in partial improvement in her facial nerve palsy. CONCLUSIONS: This case highlights a rare presentation of bilateral facial nerve palsy that likely related to paraneoplastic syndrome associated with the presence of anti-amphiphysin antibody.
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Journal title: Journal of medical case reports
Volume: 15
Pages: 158
Publication Date: 2021-03-26
Type: Journal Article
DOI: 10.1186/s13256-021-02727-3
Orcid: 0000-0002-0912-4056
Appears in Collections:(a) NT Health Research Collection

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