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dc.contributor.authorLoughland JRen
dc.contributor.authorWoodberry Ten
dc.contributor.authorOyong Den
dc.contributor.authorPiera KAen
dc.contributor.authorAmante FHen
dc.contributor.authorBarber BEen
dc.contributor.authorGrigg MJen
dc.contributor.authorWilliam Ten
dc.contributor.authorEngwerda CRen
dc.contributor.authorAnstey NMen
dc.contributor.authorMcCarthy JSen
dc.contributor.authorBoyle MJen
dc.contributor.authorMinigo Gen
dc.identifier.citationMalar J. 2021 Feb 16;20(1):97. doi: 10.1186/s12936-021-03642-0.en
dc.description.abstractBACKGROUND: Plasmodium falciparum malaria increases plasma levels of the cytokine Fms-like tyrosine kinase 3 ligand (Flt3L), a haematopoietic factor associated with dendritic cell (DC) expansion. It is unknown if the zoonotic parasite Plasmodium knowlesi impacts Flt3L or DC in human malaria. This study investigated circulating DC and Flt3L associations in adult malaria and in submicroscopic experimental infection. METHODS: Plasma Flt3L concentration and blood CD141(+) DC, CD1c(+) DC and plasmacytoid DC (pDC) numbers were assessed in (i) volunteers experimentally infected with P. falciparum and in Malaysian patients with uncomplicated (ii) P. falciparum or (iii) P. knowlesi malaria. RESULTS: Plasmodium knowlesi caused a decline in all circulating DC subsets in adults with malaria. Plasma Flt3L was elevated in acute P. falciparum and P. knowlesi malaria with no increase in a subclinical experimental infection. Circulating CD141(+) DCs, CD1c(+) DCs and pDCs declined in all adults tested, for the first time extending the finding of DC subset decline in acute malaria to the zoonotic parasite P. knowlesi. CONCLUSIONS: In adults, submicroscopic Plasmodium infection causes no change in plasma Flt3L but does reduce circulating DCs. Plasma Flt3L concentrations increase in acute malaria, yet this increase is insufficient to restore or expand circulating CD141(+) DCs, CD1c(+) DCs or pDCs. These data imply that haematopoietic factors, yet to be identified and not Flt3L, involved in the sensing/maintenance of circulating DC are impacted by malaria and a submicroscopic infection. The zoonotic P. knowlesi is similar to other Plasmodium spp in compromising DC in adult malaria.en
dc.titleReduced circulating dendritic cells in acute Plasmodium knowlesi and Plasmodium falciparum malaria despite elevated plasma Flt3 ligand levels.en
dc.typeJournal Articleen
dc.identifier.journaltitleMalaria journalen
dc.description.affiliationMenzies School of Health Research and Charles Darwin University, Darwin, Australia.
dc.description.affiliationQIMR Berghofer Medical Research Institute, Brisbane, Australia.
dc.description.affiliationMenzies School of Health Research and Charles Darwin University, Darwin, Australia.en
dc.description.affiliationQIMR Berghofer Medical Research Institute, Brisbane, Australia.en
dc.description.affiliationGleneagles Hospital, Kota Kinabalu, Sabah, Malaysia.en
dc.description.affiliationInfectious Diseases Society Kota Kinabalu Sabah-Menzies School of Research Clinical Research Unit, Kota Kinabalu, Sabah, Malaysia.en
dc.description.affiliationQueen Elizabeth Hospital-Clinical Research Centre, Ministry of Health, Kota Kinabalu, Malaysia.en
dc.description.affiliationRoyal Darwin Hospital, Darwin, Australia.en
dc.description.affiliationMenzies School of Health Research and Charles Darwin University, Darwin, Australia.
dc.description.affiliationCollege of Health and Human Sciences, Charles Darwin University, Darwin, Australia.
local.issue.number1475-2875 (Electronic)-
local.issue.number1475-2875 (Linking)-
Appears in Collections:(a) NT Health Research Collection

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