Please use this identifier to cite or link to this item: https://hdl.handle.net/10137/11612
Title: Anti-streptokinase antibodies and streptokinase resistance in an Aboriginal population in northern Australia.
Authors: Urdahl KB
Mathews JD
Currie BJ
Citation: Aust N Z J Med. 1996 Feb;26(1):49-53. doi: 10.1111/j.1445-5994.1996.tb02906.x.
Abstract: BACKGROUND: Thrombolytic treatment with streptokinase in acute myocardial infarction has proven to be safe and effective in Caucasian populations with relatively low levels of anti-streptokinase IgG and streptokinase resistance. Higher levels of antibodies, as seen in previous recipients of streptokinase therapy, cause more adverse reactions and may result in lower efficacy. AIMS: To examine the levels of anti-streptokinase IgG and streptokinase resistance in a population subjected to endemic streptococcal infections. METHODS AND RESULTS: Thirty Aboriginal adults from a remote community in Northern Australia with endemic streptococcal infections and 15 non-Aboriginal adults from an urban community without endemic infections participated in this study. Aboriginal adults exhibited levels of anti-streptokinase IgG and streptokinase resistance that, respectively, were almost 20 and 15 times greater than the values of non-Aboriginal adults. At least 23% of Aboriginal adults had sufficiently high levels of streptokinase resistance to neutralise a standard 1.5 million unit dose of streptokinase. CONCLUSIONS: Aboriginal adults from a remote community had dramatically elevated levels of anti-streptokinase IgG and in vitro streptokinase resistance. Prospective studies are needed to assess the clinical relevance of streptokinase resistance in populations from areas with endemic streptococcal infection.
Click to open Pubmed Article: https://www.ezpdhcs.nt.gov.au/login?url=https://www.ncbi.nlm.nih.gov/pubmed/8775528
Journal title: Australian and New Zealand journal of medicine
Volume: 26
Pages: 49-53
Publication Date: 1996-02
Type: Journal Article
URI: https://hdl.handle.net/10137/11612
DOI: 10.1111/j.1445-5994.1996.tb02906.x
Appears in Collections:(a) NT Health Research Collection

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