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https://hdl.handle.net/10137/11612
Title: | Anti-streptokinase antibodies and streptokinase resistance in an Aboriginal population in northern Australia. |
Authors: | Urdahl KB Mathews JD Currie BJ |
Citation: | Aust N Z J Med. 1996 Feb;26(1):49-53. doi: 10.1111/j.1445-5994.1996.tb02906.x. |
Abstract: | BACKGROUND: Thrombolytic treatment with streptokinase in acute myocardial infarction has proven to be safe and effective in Caucasian populations with relatively low levels of anti-streptokinase IgG and streptokinase resistance. Higher levels of antibodies, as seen in previous recipients of streptokinase therapy, cause more adverse reactions and may result in lower efficacy. AIMS: To examine the levels of anti-streptokinase IgG and streptokinase resistance in a population subjected to endemic streptococcal infections. METHODS AND RESULTS: Thirty Aboriginal adults from a remote community in Northern Australia with endemic streptococcal infections and 15 non-Aboriginal adults from an urban community without endemic infections participated in this study. Aboriginal adults exhibited levels of anti-streptokinase IgG and streptokinase resistance that, respectively, were almost 20 and 15 times greater than the values of non-Aboriginal adults. At least 23% of Aboriginal adults had sufficiently high levels of streptokinase resistance to neutralise a standard 1.5 million unit dose of streptokinase. CONCLUSIONS: Aboriginal adults from a remote community had dramatically elevated levels of anti-streptokinase IgG and in vitro streptokinase resistance. Prospective studies are needed to assess the clinical relevance of streptokinase resistance in populations from areas with endemic streptococcal infection. |
Click to open Pubmed Article: | https://www.ezpdhcs.nt.gov.au/login?url=https://www.ncbi.nlm.nih.gov/pubmed/8775528 |
Journal title: | Australian and New Zealand journal of medicine |
Volume: | 26 |
Pages: | 49-53 |
Publication Date: | 1996-02 |
Type: | Journal Article |
URI: | https://hdl.handle.net/10137/11612 |
DOI: | 10.1111/j.1445-5994.1996.tb02906.x |
Appears in Collections: | (a) NT Health Research Collection |
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