Urdahl KB; Mathews JD; Currie, Bart

Author(s)

Urdahl KB

Mathews JD

Currie, Bart

Publication Date

1996-02-01

Abstract

BACKGROUND: Thrombolytic treatment with streptokinase in acute myocardial infarction has proven to be safe and effective in Caucasian populations with relatively low levels of anti-streptokinase IgG and streptokinase resistance. Higher levels of antibodies, as seen in previous recipients of streptokinase therapy, cause more adverse reactions and may result in lower efficacy. AIMS: To examine the levels of anti-streptokinase IgG and streptokinase resistance in a population subjected to endemic streptococcal infections. METHODS AND RESULTS: Thirty Aboriginal adults from a remote community in Northern Australia with endemic streptococcal infections and 15 non-Aboriginal adults from an urban community without endemic infections participated in this study. Aboriginal adults exhibited levels of anti-streptokinase IgG and streptokinase resistance that, respectively, were almost 20 and 15 times greater than the values of non-Aboriginal adults. At least 23% of Aboriginal adults had sufficiently high levels of streptokinase resistance to neutralise a standard 1.5 million unit dose of streptokinase. CONCLUSIONS: Aboriginal adults from a remote community had dramatically elevated levels of anti-streptokinase IgG and in vitro streptokinase resistance. Prospective studies are needed to assess the clinical relevance of streptokinase resistance in populations from areas with endemic streptococcal infection.

Affiliation

Department of Microbiology, University of Minnesota Medical School, Minneapolis, USA.

Citation

Aust N Z J Med. 1996 Feb;26(1):49-53. doi: 10.1111/j.1445-5994.1996.tb02906.x.

Pubmed ID

https://pubmed.ncbi.nlm.nih.gov/8775528/?otool=iaurydwlib

Link

https://hdl.handle.net/10137/11612

Volume

26

Subject

Adult

Antibodies, Anti-Idiotypic

Drug Resistance, Microbial/immunology

Enzyme-Linked Immunosorbent Assay

Humans

Immunoglobulin G/*immunology

Middle Aged

Northern Territory

*Oceanic Ancestry Group

Streptococcal Infections/drug therapy/*immunology

Streptokinase/*immunology/therapeutic use

Title

Anti-streptokinase antibodies and streptokinase resistance in an Aboriginal population in northern Australia.

Type of document

Journal Article

Entity Type

Publication

Author(s)	Urdahl KB Mathews JD Currie, Bart
Publication Date	1996-02-01
Abstract	BACKGROUND: Thrombolytic treatment with streptokinase in acute myocardial infarction has proven to be safe and effective in Caucasian populations with relatively low levels of anti-streptokinase IgG and streptokinase resistance. Higher levels of antibodies, as seen in previous recipients of streptokinase therapy, cause more adverse reactions and may result in lower efficacy. AIMS: To examine the levels of anti-streptokinase IgG and streptokinase resistance in a population subjected to endemic streptococcal infections. METHODS AND RESULTS: Thirty Aboriginal adults from a remote community in Northern Australia with endemic streptococcal infections and 15 non-Aboriginal adults from an urban community without endemic infections participated in this study. Aboriginal adults exhibited levels of anti-streptokinase IgG and streptokinase resistance that, respectively, were almost 20 and 15 times greater than the values of non-Aboriginal adults. At least 23% of Aboriginal adults had sufficiently high levels of streptokinase resistance to neutralise a standard 1.5 million unit dose of streptokinase. CONCLUSIONS: Aboriginal adults from a remote community had dramatically elevated levels of anti-streptokinase IgG and in vitro streptokinase resistance. Prospective studies are needed to assess the clinical relevance of streptokinase resistance in populations from areas with endemic streptococcal infection.
Affiliation	Department of Microbiology, University of Minnesota Medical School, Minneapolis, USA.
Citation	Aust N Z J Med. 1996 Feb;26(1):49-53. doi: 10.1111/j.1445-5994.1996.tb02906.x.
Pubmed ID	https://pubmed.ncbi.nlm.nih.gov/8775528/?otool=iaurydwlib
Link	https://hdl.handle.net/10137/11612
Volume	26
Subject	Adult Antibodies, Anti-Idiotypic Drug Resistance, Microbial/immunology Enzyme-Linked Immunosorbent Assay Humans Immunoglobulin G/immunology Middle Aged Northern Territory Oceanic Ancestry Group Streptococcal Infections/drug therapy/immunology Streptokinase/immunology/therapeutic use
Title	Anti-streptokinase antibodies and streptokinase resistance in an Aboriginal population in northern Australia.
Type of document	Journal Article
Entity Type	Publication

Anti-streptokinase antibodies and streptokinase resistance in an Aboriginal population in northern Australia.

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