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Title: Anti-streptokinase antibodies and streptokinase resistance in an Aboriginal population in northern Australia.
Authors: Urdahl KB
Mathews JD
Currie BJ
Citation: Aust N Z J Med. 1996 Feb;26(1):49-53. doi: 10.1111/j.1445-5994.1996.tb02906.x.
Abstract: BACKGROUND: Thrombolytic treatment with streptokinase in acute myocardial infarction has proven to be safe and effective in Caucasian populations with relatively low levels of anti-streptokinase IgG and streptokinase resistance. Higher levels of antibodies, as seen in previous recipients of streptokinase therapy, cause more adverse reactions and may result in lower efficacy. AIMS: To examine the levels of anti-streptokinase IgG and streptokinase resistance in a population subjected to endemic streptococcal infections. METHODS AND RESULTS: Thirty Aboriginal adults from a remote community in Northern Australia with endemic streptococcal infections and 15 non-Aboriginal adults from an urban community without endemic infections participated in this study. Aboriginal adults exhibited levels of anti-streptokinase IgG and streptokinase resistance that, respectively, were almost 20 and 15 times greater than the values of non-Aboriginal adults. At least 23% of Aboriginal adults had sufficiently high levels of streptokinase resistance to neutralise a standard 1.5 million unit dose of streptokinase. CONCLUSIONS: Aboriginal adults from a remote community had dramatically elevated levels of anti-streptokinase IgG and in vitro streptokinase resistance. Prospective studies are needed to assess the clinical relevance of streptokinase resistance in populations from areas with endemic streptococcal infection.
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Journal title: Australian and New Zealand journal of medicine
Volume: 26
Pages: 49-53
Publication Date: 1996-02
Type: Journal Article
DOI: 10.1111/j.1445-5994.1996.tb02906.x
Appears in Collections:(a) NT Health Research Collection

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