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Title: Molecular Antimicrobial Resistance Surveillance for Neisseria gonorrhoeae, Northern Territory, Australia.
Authors: Whiley DM
Trembizki E
Buckley C
Freeman K
Baird RW
Beaman M
Chen M
Donovan B
Kundu RL
Fairley CK
Guy R
Hogan T
Kaldor JM
Karimi M
Limnios A
Regan DG
Ryder N
Su J-Y
Ward J
Lahra MM
Citation: Emerg Infect Dis. 2017 Sep;23(9):1478-1485. doi: 10.3201/eid2309.170427.
Abstract: Neisseria gonorrhoeae antimicrobial resistance (AMR) is a globally recognized health threat; new strategies are needed to enhance AMR surveillance. The Northern Territory of Australia is unique in that 2 different first-line therapies, based primarily on geographic location, are used for gonorrhea treatment. We tested 1,629 N. gonorrhoeae nucleic acid amplification test-positive clinical samples, collected from regions where ceftriaxone plus azithromycin or amoxicillin plus azithromycin are recommended first-line treatments, by using 8 N. gonorrhoeae AMR PCR assays. We compared results with those from routine culture-based surveillance data. PCR data confirmed an absence of ceftriaxone resistance and a low level of azithromycin resistance (0.2%), and that penicillin resistance was <5% in amoxicillin plus azithromycin regions. Rates of ciprofloxacin resistance and penicillinase-producing N. gonorrhoeae were lower when molecular methods were used. Molecular methods to detect N. gonorrhoeae AMR can increase the evidence base for treatment guidelines, particularly in settings where culture-based surveillance is limited.
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Journal title: Emerging infectious diseases
Volume: 23
Pages: 1478-1485
Publication Date: 2017-09
Type: Journal Article
DOI: 10.3201/eid2309.170427
Appears in Collections:(a) NT Health Research Collection

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