Smith S; Hanson J; Currie, Bart

Author(s)

Smith S

Hanson J

Currie, Bart

Publication Date

2018-03-01

Abstract

Burkholderia pseudomallei is endemic in northern Australia, with cases of melioidosis most commonly occurring during the wet season in individuals with diabetes, hazardous alcohol use, and chronic kidney disease. Pneumonia is the most common presentation and the majority of patients are bacteraemic-however, infection may involve almost any organ, with the skin and soft tissues, genitourinary system, visceral organs, and bone and joints affected most commonly. Central nervous system involvement is rarer, but has a high attributable mortality. Increased awareness of the disease amongst healthcare providers, ready access to appropriate antibiotic therapy and high-quality intensive care services has resulted in a sharp decline in the case fatality rate over the last 20 years. Further improvement in clinical outcomes will require a greater understanding of the disease's pathophysiology, its optimal management, and more effective strategies for its prevention.

Affiliation

Department of Medicine, Cairns Hospital, Cairns, QLD 4870, Australia. simon.smith2@health.qld.gov.au.

James Cook University Clinical School, Cairns Hospital, Cairns, QLD 4870, Australia. simon.smith2@health.qld.gov.au.

Department of Medicine, Cairns Hospital, Cairns, QLD 4870, Australia. Joshua.Hanson@health.qld.gov.au.

Global and Tropical Health Division, Menzies School of Health Research, Charles Darwin University, Darwin, NT 0811, Australia. Joshua.Hanson@health.qld.gov.au.

The Kirby Institute, University of New South Wales, Sydney, NSW 2052, Australia. Joshua.Hanson@health.qld.gov.au.

Global and Tropical Health Division, Menzies School of Health Research, Charles Darwin University, Darwin, NT 0811, Australia. Bart.Currie@menzies.edu.au.

Department of Infectious Diseases, Royal Darwin Hospital, Darwin, NT 0811, Australia. Bart.Currie@menzies.edu.au.

Citation

Trop Med Infect Dis. 2018 Mar 1;3(1):27. doi: 10.3390/tropicalmed3010027.

OrcId

0000-0002-1423-3839

0000-0002-8878-8837

Pubmed ID

https://pubmed.ncbi.nlm.nih.gov/30274424/?otool=iaurydwlib

Link

https://hdl.handle.net/10137/11418

Volume

3

Title

Melioidosis: An Australian Perspective.

Type of document

Journal Article

Entity Type

Publication

Author(s)	Smith S Hanson J Currie, Bart
Publication Date	2018-03-01
Abstract	Burkholderia pseudomallei is endemic in northern Australia, with cases of melioidosis most commonly occurring during the wet season in individuals with diabetes, hazardous alcohol use, and chronic kidney disease. Pneumonia is the most common presentation and the majority of patients are bacteraemic-however, infection may involve almost any organ, with the skin and soft tissues, genitourinary system, visceral organs, and bone and joints affected most commonly. Central nervous system involvement is rarer, but has a high attributable mortality. Increased awareness of the disease amongst healthcare providers, ready access to appropriate antibiotic therapy and high-quality intensive care services has resulted in a sharp decline in the case fatality rate over the last 20 years. Further improvement in clinical outcomes will require a greater understanding of the disease's pathophysiology, its optimal management, and more effective strategies for its prevention.
Affiliation	Department of Medicine, Cairns Hospital, Cairns, QLD 4870, Australia. simon.smith2@health.qld.gov.au. James Cook University Clinical School, Cairns Hospital, Cairns, QLD 4870, Australia. simon.smith2@health.qld.gov.au. Department of Medicine, Cairns Hospital, Cairns, QLD 4870, Australia. Joshua.Hanson@health.qld.gov.au. Global and Tropical Health Division, Menzies School of Health Research, Charles Darwin University, Darwin, NT 0811, Australia. Joshua.Hanson@health.qld.gov.au. The Kirby Institute, University of New South Wales, Sydney, NSW 2052, Australia. Joshua.Hanson@health.qld.gov.au. Global and Tropical Health Division, Menzies School of Health Research, Charles Darwin University, Darwin, NT 0811, Australia. Bart.Currie@menzies.edu.au. Department of Infectious Diseases, Royal Darwin Hospital, Darwin, NT 0811, Australia. Bart.Currie@menzies.edu.au.
Citation	Trop Med Infect Dis. 2018 Mar 1;3(1):27. doi: 10.3390/tropicalmed3010027.
OrcId	0000-0002-1423-3839 0000-0002-8878-8837
Pubmed ID	https://pubmed.ncbi.nlm.nih.gov/30274424/?otool=iaurydwlib
Link	https://hdl.handle.net/10137/11418
Volume	3
Title	Melioidosis: An Australian Perspective.
Type of document	Journal Article
Entity Type	Publication

Melioidosis: An Australian Perspective.

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