Heraganahally SS

Zaw KK

Tip S

Jing X

Mingi JJ

Howarth T

Roy A

Falhammar H

Sajkov D

2020-10-04

BACKGROUND: Clinical characteristics of women with different obstructive sleep apnoea (OSA) severity and adherence to Continuous Positive Airway Pressure (CPAP) therapy have not been previously explored. Therefore, in this retrospective study we assessed OSA prevalence. predictors, clinical and polysomnographic (PSG) characteristics and adherence to CPAP therapy among adult Australian women. METHODS: All female patients who underwent a diagnostic PSG between 2014/2015 were included. CPAP adherence was assessed during the study period between 2018/2019 using multiple regression model. RESULTS: Among a total of 591 females included in this study (Aboriginal n=86), OSA was diagnosed in 458/591 (78%) patients; mild, moderate and severe OSA was present in 44%, 27% and 29% respectively. Older age, higher BMI and hypertension predicted the presence and severity of OSA. The Epworth Sleepiness Scale (ESS) score was not significantly different with [10 (5, 13)] or without [8 (5, 12)] OSA. PSG showed rapid eye movement (REM) sleep associated apnoea hypopnea index (AHI) was higher with all severity of OSA. Adherence to CPAP therapy was noted in 171 (57%) patients; 47% mild, 57% moderate and 63% with severe OSA respectively. Three multiple regression models [clinical, PSG parameters, OSA severity, combined (clinical and PSG)] showed combined model had strongest predictive value and demonstrated that higher ESS and more severe oxygen desaturation were associated with CPAP adherence irrespective of OSA severity. CONCLUSION: Older age, higher BMI and presence of hypertension predicted the presence of OSA. REM sleep related AHI was higher. Adherence to CPAP was associated with symptomatic OSA and severe oxygen desaturation. This article is protected by copyright. All rights reserved.

Department of Respiratory and Sleep Medicine, Royal Darwin Hospital, Darwin, Northern Territory, Australia.

College of Medicine and Public Health, Flinders University, Adelaide, South Australia, Australia and Northern Territory Medical Program, Darwin, Northern Territory, Australia.

Darwin Respiratory and Sleep Health, Darwin private Hospital, Darwin, Northern Territory, Australia.

Australian Respiratory and Sleep Medicine Institute, Adelaide, Australia.

Department of General Practice, Northern Territory, Darwin, Australia.

Health Information Services, Royal Darwin Hospital, Darwin, Northern Territory, Australia.

Department of Public Health, Charles Darwin University, Darwin, Northern Territory, Australia.

College of Health and Human Sciences, Charles Darwin University, Darwin, Northern Territory, Australia.

Department of Respiratory and Sleep Medicine, The Queen Elizabeth Hospital, South Australia, Australia.

Departments of General Medicine and Endocrinology, Royal Darwin Hospital, Darwin, Northern Territory, Australia.

Menzies School of Health Research, Darwin, Northern Territory, Australia.

Department of Endocrinology, Metabolism and Diabetes, Karolinska University Hospital, Stockholm, Sweden and Department of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden.

Respiratory and Sleep Medicine, Flinders Medical Centre, Bedford Park, Adelaide, South Australia, Australia.

This article is protected by copyright. All rights reserved.

Intern Med J. 2020 Oct 4. doi: 10.1111/imj.15076.

0000-0003-0788-7137

https://pubmed.ncbi.nlm.nih.gov/33012105/?otool=iaurydwlib

https://hdl.handle.net/10137/11410

Obstructive sleep apnoea and adherence to continuous positive airway therapy among Australian women.

Journal Article

Publication