Please use this identifier to cite or link to this item: https://hdl.handle.net/10137/11393
Title: Global and regional dissemination and evolution of Burkholderia pseudomallei.
Authors: Chewapreecha C
Holden MTG
Vehkala M
Välimäki N
Yang Z
Harris SR
Mather AE
Tuanyok A
De Smet B
Le Hello S
Bizet C
Mayo MJ
Wuthiekanun V
Limmathurotsakul D
Phetsouvanh R
Spratt BG
Corander J
Keim P
Dougan G
Dance DAB
Currie BJ
Parkhill J
Peacock SJ
Citation: Nat Microbiol. 2017 Jan 23;2:16263. doi: 10.1038/nmicrobiol.2016.263.
Abstract: The environmental bacterium Burkholderia pseudomallei causes an estimated 165,000 cases of human melioidosis per year worldwide and is also classified as a biothreat agent. We used whole genome sequences of 469 B. pseudomallei isolates from 30 countries collected over 79 years to explore its geographic transmission. Our data point to Australia as an early reservoir, with transmission to Southeast Asia followed by onward transmission to South Asia and East Asia. Repeated reintroductions were observed within the Malay Peninsula and between countries bordered by the Mekong River. Our data support an African origin of the Central and South American isolates with introduction of B. pseudomallei into the Americas between 1650 and 1850, providing a temporal link with the slave trade. We also identified geographically distinct genes/variants in Australasian or Southeast Asian isolates alone, with virulence-associated genes being among those over-represented. This provides a potential explanation for clinical manifestations of melioidosis that are geographically restricted.
Click to open Pubmed Article: https://www.ezpdhcs.nt.gov.au/login?url=https://www.ncbi.nlm.nih.gov/pubmed/28112723
Journal title: Nature microbiology
Volume: 2
Pages: 16263
Publication Date: 2017-01-23
Type: Journal Article
URI: https://hdl.handle.net/10137/11393
DOI: 10.1038/nmicrobiol.2016.263
Orcid: 0000-0002-4958-2166
0000-0003-1512-6194
0000-0001-9189-7244
0000-0002-7069-5958
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