Ostrowski JA

MacLaren G

Alexander J

Stewart, Penny

Gune Sheena

Francis JR

Ganu S

Festa M

Erickson SJ

Straney L

Schlapbach LJ

2017-02-06

To describe the incidence and mortality of invasive infections in Indigenous children admitted to paediatric and general intensive care units (ICUs) in Australia. Retrospective multi-centre cohort study of Australian and New Zealand Paediatric Intensive Care Registry data. All children under 16 years of age admitted to an ICU in Australia, 1 January 2002 - 31 December 2013. Indigenous children were defined as those identified as Aboriginal and/or Torres Strait Islander in a mandatory admissions dataset. Population-based ICU mortality and admission rates. Invasive infections accounted for 23.0% of non-elective ICU admissions of Indigenous children (726 of 3150), resulting in an admission rate of 47.6 per 100 000 children per year. Staphylococcus aureus was the leading pathogen identified in children with sepsis/septic shock (incidence, 4.42 per 100 000 Indigenous children per year; 0.57 per 100 000 non-Indigenous children per year; incidence rate ratio 7.7; 95% CI, 5.8-10.1; P < 0.001). While crude and risk-adjusted ICU mortality related to invasive infections was not significantly different for Indigenous and non-Indigenous children (odds ratio, 0.75; 95% CI, 0.53-1.07; P = 0.12), the estimated population-based age-standardised mortality rate for invasive infections was significantly higher for Indigenous children (2.67 per 100 000 per year v 1.04 per 100 000 per year; crude incidence rate ratio, 2.65; 95% CI, 1.88-3.64; P < 0.001). The ICU admission rate for severe infections was several times higher for Indigenous than for non-Indigenous children, particularly for S. aureus infections. While ICU case fatality rates were similar, the population-based mortality was more than twice as high for Indigenous children. Our study highlights an important area of inequality in health care for Indigenous children in a high income country that needs urgent attention.

The Medical journal of Australia 2017-02-06; 206(2): 78-84

https://pubmed.ncbi.nlm.nih.gov/28152345/?otool=iaurydwlib

https://hdl.handle.net/10137/5286

Adolescent

Australia

Child

Child, Hospitalized

Child, Preschool

Cohort Studies

Critical Care Outcomes

Critical Illness

Female

Healthcare Disparities

Humans

Incidence

Infant

Infant, Newborn

Intensive Care Units

Male

Mortality

New Zealand

Population Groups

Retrospective Studies

Sepsis

Severity of Illness Index

Staphylococcal Infections

Staphylococcus aureus

Survival Analysis

Cost of Illness

The burden of invasive infections in critically ill Indigenous children in Australia.

Journal Article

Publication