Arnold, Luke W

Hoy, Wendy E

Sharma, Suresh K

Wang, Zhiqiang

2016

This study investigates the burden of cardiovascular risk markers in people with and without diabetes in a remote Indigenous Australian community, based on their HbA1c concentration. This study included health screening exams of 1187 remote Indigenous residents over 15 years old who represented 70% of the age-eligible community. The participants were stratified by HbA1c into 5 groups using cut-off points recommended by international organisations. The associations of traditional cardiovascular risk markers with HbA1c groups were assessed using logistic and linear regressions and ANOVA models. Of the 1187 participants, 158 (13%) had a previous diabetes diagnosis, up to 568 (48%) were at high risk (5.7-6.4% (39-46 mmol/mol) HbA1c), and 67 (6%) potential new cases of diabetes (≥6.5% (48 mmol/mol)) were identified. Individuals with higher HbA1c levels were more likely to have albuminuria (OR 3.14, 95% CI 1.26-7.82) and dyslipidaemia (OR 2.37, 95% CI 1.29-4.34) and visited the clinic more often (OR 2.52, 95% CI 1.26-4.99). Almost all traditional CVD risk factors showed a positive association with HbA1c. Screening in this remote Indigenous Australian community highlights the high proportion of individuals who are at high risk of diabetes as indicated by HbA1c and who also had an accentuated cardiovascular risk profile.

Centre for Chronic Disease, The University of Queensland School of Medicine, Royal Brisbane & Women's Hospital, Health Sciences Building Level 8, Herston, QLD 4029, Australia..

Centre for Chronic Disease, The University of Queensland School of Medicine, Royal Brisbane & Women's Hospital, Health Sciences Building Level 8, Herston, QLD 4029, Australia..

Division of Medicine, Royal Darwin Hospital, Top End Health Network, Northern Territory Government, Tiwi, NT 0810, Australia..

Centre for Chronic Disease, The University of Queensland School of Medicine, Royal Brisbane & Women's Hospital, Health Sciences Building Level 8, Herston, QLD 4029, Australia..

Journal of diabetes research 2016; 2016: 5342304

https://pubmed.ncbi.nlm.nih.gov/26989697/?otool=iaurydwlib

https://hdl.handle.net/10137/5368

Adult

Albuminuria

Australia

Biomarkers

Cardiovascular Diseases

Comorbidity

Diabetes Mellitus

Dyslipidemias

Female

Glycated Hemoglobin A

Humans

Linear Models

Logistic Models

Male

Odds Ratio

Risk Assessment

Risk Factors

Young Adult

Oceanic Ancestry Group

Rural Health

The Association between HbA1c and Cardiovascular Disease Markers in a Remote Indigenous Australian Community with and without Diagnosed Diabetes.

Comparative Study

Journal Article

Publication