To, Xuan Vinh

Zhu, Ning

Mohamed, Abdalla Z

Fleming, Jennifer

Hamilton, Caitlin

Swan, Sarah

Campbell, Megan E J

Campbell, Lewis

Ownsworth, Tamara

Shum, David H K

Nasrallah, Fatima

2024-11-20

Prospective memory (PM) impairment is a common consequence of moderate-severe traumatic brain injury (TBI). Compensatory strategy training and rehabilitation (COMP) is the usual treatment of PM deficits through environmental modification and the use of assistive methods such as diaries and routines. The study intends to examine the changes in white matter integrity, as measured by advanced diffusion magnetic resonance imaging (dMRI) following COMP intervention in moderate-severe TBI patients. Nine COMP intervention and twelve routine care comparison cohort moderate-severe TBI patients were recruited from level 1 trauma centres in the Brisbane metropolitan area. Both groups were imaged at least one-month post-TBI for a baseline scan. COMP group was imaged again after a 6-week COMP intervention program and the comparison group was imaged again at least 6 weeks after the baseline scan. MRI scan included structural imaging and dMRI, which the latter fitted for the Neurite Orientation Dispersion and Density Imaging (NODDI) model. Only the comparison group had decreased Neurite Density Index in the major white matter tracts and increased isotropic diffusion in the fluid space between the cortical folds. Our results indicated that COMP intervention slowed down the neural degeneration in moderate-severe TBI patients as compared to routine medical care/rehabilitation.

Queensland Brain Institute, University of Queensland, Brisbane, Australia.

Queensland Brain Institute, University of Queensland, Brisbane, Australia.

Department of Neurosurgery, Princess Alexandra Hospital, Brisbane, Australia.

Queensland Brain Institute, University of Queensland, Brisbane, Australia.

Center for Brain and Health, New York University Abu Dhabi, Abu Dhabi, United Arab Emirates.

School of Health & Rehabilitation Sciences, University of Queensland, Brisbane, Australia.

School of Health & Rehabilitation Sciences, University of Queensland, Brisbane, Australia.

School of Health & Rehabilitation Sciences, University of Queensland, Brisbane, Australia.

Queensland Brain Institute, University of Queensland, Brisbane, Australia.

Hunter Medical Research Institute, University of Newcastle, Newcastle, Australia.

Intensive Care Unit, Royal Darwin Hospital, Darwin, Australia.

College of Medicine and Public Health, Flinders University, Adelaide, Australia.

School of Applied Psychology & The Hopkins Centre, Menzies Health Institute Queensland, Griffith University, Nathan, Australia.

Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Kowloon, Hong Kong.

Queensland Brain Institute, University of Queensland, Brisbane, Australia.

Neuropsychol Rehabil . 2024 Nov 20:1-21. doi: 10.1080/09602011.2024.2423861. Online ahead of print.

1464-0694

0000-0002-6527-7356

0000-0003-1835-7094

https://pubmed.ncbi.nlm.nih.gov/39565109/?otool=iaurydwlib

https://hdl.handle.net/10137/13824

Memory

brain injuries

diffusion tensor imaging

episodic

magnetic resonance imaging

occupational therapy

rehabilitation

traumatic

Microstructural brain changes following prospective memory rehabilitation in traumatic brain injury: An observational study.

Journal Article

Publication