Al-Maqbali, Juhaina Salim

Al Alawi, Abdullah

Abeyaratne, Asanga

Majoni, Sandawana William

Falhammar, Henrik

2024-07-25

Magnesium is an essential cation, and dysmagnesaemia is linked to many poor outcomes. This study aimed to assess the prevalence of dysmagnesaemia and associated health outcomes among hospitalised patients.This register-based study collected demographic and laboratory data of hospitalised patients from five publicly funded hospitals in the Northern Territory, Australia, between 2008 and 2017. Patients were stratified into five groups based on their initial serum magnesium level at admission and followed up to death or 31 December 2017.A total of 22 293 patients were admitted during the study period. Dysmagnesaemia was present in 31.75% of hospitalised patients, with hypomagnesaemia being more common (29.62%) than hypermagnesaemia (2.13%). Hypomagnesaemia was more prevalent (43.13%) among the Australian First Nations Peoples. All levels of hypomagnesaemia were associated with a longer median length of hospital stay (p<0.001). Also, all levels of hypermagnesaemia were associated with a longer median stay in intensive care units (p<0.001). Patients with severe hypermagnesaemia had increased mortality compared to patients with severe hypomagnesaemia (56.0% v 38.0.0%, p<0.0001). Mortality was increased in both hypomagnesaemia (hazard ratio 1.86, 95% confidence intervaI 1.74-1.99, p<0.001) and hypermagnesaemia (1.78, 1.48-2.19, p<0.001) compared to normomagnesaemia.Dysmagnesaemia was prevalent among hospitalised patients and associated with increased mortality.

Department of Pharmacology and Clinical Pharmacy, College of Medicine and Health Science, Sultan Qaboos University, Muscat, Oman.

Department of Pharmacy, Sultan Qaboos University Hospital, Muscat, Oman.

Department of Medicine, Sultan Qaboos University Hospital, Muscat, Oman.

Internal Medicine Residency Training Program, Oman Medical Specialty Board, Muscat, Oman.

Department of Nephrology, Division of Medicine, Royal Darwin Hospital, Darwin, NT, Australia.

Royal Darwin Hospital Campus, Northern Territory Clinical School, Flinders University, Darwin, NT, Australia.

Menzies School of Health Research, Charles Darwin University, Darwin, NT, Australia.

Department of Nephrology, Division of Medicine, Royal Darwin Hospital, Darwin, NT, Australia.

Royal Darwin Hospital Campus, Northern Territory Clinical School, Flinders University, Darwin, NT, Australia.

Menzies School of Health Research, Charles Darwin University, Darwin, NT, Australia.

Division of Medicine, Royal Darwin Hospital, Darwin, NT, Australia.

Department of Endocrinology, Karolinska University Hospital, Stockholm, Sweden.

Department of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden.

Rural Remote Health . 2024 Jul;24(3):8515. doi: 10.22605/RRH8515. Epub 2024 Jul 25.

1445-6354

https://pubmed.ncbi.nlm.nih.gov/39075781/?otool=iaurydwlib

https://hdl.handle.net/10137/13494

Indigenous

hospitalisation

length of stay

magnesium

mortality

Australian First Nations

Humans

Northern Territory

Female

Male

Retrospective Studies

Middle Aged

Aged

Hospitalization

Magnesium

Longitudinal Studies

Adult

Magnesium Deficiency

Length of Stay

Prevalence

Clinical outcomes in patients hospitalised with dysmagnesemia in the Northern Territory of Australia: a retrospective, longitudinal data-linkage study.

Journal Article

Publication