Bowen AC; Carapetis J

Advances in the diagnosis and management of central venous access device infections in children.

Author(s)

Bowen AC

Carapetis J

Publication Date

2011

Abstract

Infection is a well-known complication of central venous access device (CVAD) use, with an incidence of 3-6 bloodstream infections per 1,000 catheter days in children. Prevention of CVAD infections has improved with new strategies including the use of chlorhexidine antisepsis, bundles, maximal sterile barriers for insertion, prophylactic locks, antibiotic impregnated catheters and tunnelling of long-term devices. Despite these strategies, catheter-related bloodstream infections (CRBSIs) continue to be an important health problem. New approaches to diagnosis include differential time to positivity and quantification of blood cultures and molecular diagnostics. The management of CRBSIs includes techniques for line salvage including ethanol, antibiotic, hydrochloric acid, taurolidine and urokinase locks. When these fail, line removal and antimicrobial therapy are recommended.

Affiliation

Paediatric Infectious Diseases, Alice Springs Hospital, Alice Springs, Northern Territory, Australia..

Citation

Advances in experimental medicine and biology 2011; 697: 91-106

ISSN

0065-2598

Pubmed ID

https://pubmed.ncbi.nlm.nih.gov/21120722/?otool=iaurydwlib

Link

https://hdl.handle.net/10137/5706

MESH subject

Child

Humans

Infection Control

Bacterial Infections

Catheterization, Central Venous

Title

Advances in the diagnosis and management of central venous access device infections in children.

Type of document

Journal Article

Review

Entity Type

Publication

Author(s)	Bowen AC Carapetis J
Publication Date	2011
Abstract	Infection is a well-known complication of central venous access device (CVAD) use, with an incidence of 3-6 bloodstream infections per 1,000 catheter days in children. Prevention of CVAD infections has improved with new strategies including the use of chlorhexidine antisepsis, bundles, maximal sterile barriers for insertion, prophylactic locks, antibiotic impregnated catheters and tunnelling of long-term devices. Despite these strategies, catheter-related bloodstream infections (CRBSIs) continue to be an important health problem. New approaches to diagnosis include differential time to positivity and quantification of blood cultures and molecular diagnostics. The management of CRBSIs includes techniques for line salvage including ethanol, antibiotic, hydrochloric acid, taurolidine and urokinase locks. When these fail, line removal and antimicrobial therapy are recommended.
Affiliation	Paediatric Infectious Diseases, Alice Springs Hospital, Alice Springs, Northern Territory, Australia..
Citation	Advances in experimental medicine and biology 2011; 697: 91-106
ISSN	0065-2598
Pubmed ID	https://pubmed.ncbi.nlm.nih.gov/21120722/?otool=iaurydwlib
Link	https://hdl.handle.net/10137/5706
MESH subject	Child Humans Infection Control Bacterial Infections Catheterization, Central Venous
Title	Advances in the diagnosis and management of central venous access device infections in children.
Type of document	Journal Article Review
Entity Type	Publication

Advances in the diagnosis and management of central venous access device infections in children.

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