Zala, Aakansha

Berhane, Thomas

Juhlin, C Christofer

Calissendorff, Jan

Falhammar, Henrik

2020-07-20

CONTEXT: Riedel's thyroiditis (RT) is a rare inflammatory autoimmune disease that is often a clinically diagnostic dilemma due to its insidious presentation and non-specific symptoms. OBJECTIVE: The aim of the present systematic review and meta-analysis is to clarify the presentation, management and outcomes of RT. STUDY SELECTION: A systematic search of PubMed/MEDLINE and Web of Science was conducted to identify relevant reports published up to September 2019. DATA EXTRACTION: First author, country, patient sex, ethnicity, presentation, biochemical status, duration of symptoms, histology, treatment, follow-up duration, and short- and long-term outcomes. DATA SYNTHESIS: Data from 212 RT patients was retrieved. The mean age was 47 years with a predominantly female population (81%). Neck swelling (89%), dyspnea (50%), neck pain (41%) were the most common presenting symptoms. Inflammatory markers were elevated in 70-97% and thyroid antibody positivity was present in less than 50%. Up to 82% underwent surgical intervention, with the most common being total thyroidectomy in 34% of individuals. Glucocorticoids were utilized in 70% of individuals with median duration 3 months. Prognosis was reasonable with 90% having resolution or improvement of symptoms. CONCLUSIONS: This analysis is the largest and most comprehensive to date of RT and provides clinicians with vital information on the common presentation features that may alert to the diagnosis and to highlight management options.

Department of Endocrinology, Royal Darwin Hospital, Northern Territory, Australia.

Department of Endocrinology, Gold Coast University Hospital, Queensland, Australia.

Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden.

Department of Pathology and Cytology, Karolinska University Hospital, Stockholm, Sweden.

Department of Endocrinology, Metabolism and Diabetes, Karolinska University Hospital, Stockholm, Sweden.

Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.

Menzies School of Health Research, Darwin, Northern Territory, Australia.

© Endocrine Society 2020. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

J Clin Endocrinol Metab. 2020 Jul 20:dgaa468. doi: 10.1210/clinem/dgaa468.

https://pubmed.ncbi.nlm.nih.gov/32687163/?otool=iaurydwlib

https://hdl.handle.net/10137/8551

Riedel's Thyroiditis.

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