Thompson, Fintan

Russell, Sarah

Quigley, Rachel

McDonald, Malcolm

Sagigi, Betty

Taylor, Sean

Campbell, Sandy

Schmidt, Barbara

Esterman, Adrian

Harriss, Linton R

Miller, Gavin

Mills, Phillip

Strivens, Edward

McDermott, Robyn

2023-07-31

Dementia disproportionately affects First Nations populations. Biomarkers collected in primary care may assist with determining dementia risk. Our previous underpowered study showed some suggestive associations between baseline biomarkers with follow-up dementia or cognitive impairment. The current study extended this work with a larger linked dataset.Probabilistic data linkage was used to combine four baseline datasets with one follow-up assessment of dementia status 0-20 years later in a First Nations population in Australia. Mixed Effects Generalized Linear Regression models were used to test associations between baseline measures and follow-up status, accounting for repeated measures within individuals.Linked data were available for 88 individuals, with 101-279 baseline observations, depending on the type of measure. Higher urinary albumin to creatine ratio was associated with greater risk of cognitive impairment/dementia, whereas body weight and key lipid markers were negatively associated. There was no clear trend when these associations were examined by timing of measurement (i.e., ≤10 years or >10 years before a dementia assessment).The results of this study support findings from our previous work and indicate that microalbuminuria can be an early indicator of dementia risk in this population. The weight and lipid profile findings reflect the mixed results in the published literature and require further investigation and interpretation.

Australian Institute of Tropical Health and Medicine, College of Public Health, Medical and Veterinary Sciences, James Cook University, Cairns, QLD, Australia.

School of Health Sciences, University of South Australia, Adelaide, SA, Australia.

College of Medicine and Dentistry, James Cook University, Cairns, QLD, Australia.

Queensland Health, Cairns and Hinterland Hospital and Health Service, Cairns, QLD, Australia.

College of Medicine and Dentistry, James Cook University, Cairns, QLD, Australia.

Queensland Health, Cairns and Hinterland Hospital and Health Service, Cairns, QLD, Australia.

Australian Institute of Tropical Health and Medicine, College of Public Health, Medical and Veterinary Sciences, James Cook University, Cairns, QLD, Australia.

Queensland Health, Torres and Cape Hospital and Health Service, Thursday Island, QLD, Australia.

Top End Health Service, Northern Territory Government, Darwin, NT, Australia.

Molly Wardaguga Research Centre, Charles Darwin University, Brisbane, QLD, Australia.

Australian Institute of Tropical Health and Medicine, College of Public Health, Medical and Veterinary Sciences, James Cook University, Cairns, QLD, Australia.

School of Health Sciences, University of South Australia, Adelaide, SA, Australia.

Australian Institute of Tropical Health and Medicine, College of Public Health, Medical and Veterinary Sciences, James Cook University, Cairns, QLD, Australia.

Queensland Health, Cairns and Hinterland Hospital and Health Service, Cairns, QLD, Australia.

Queensland Health, Cairns and Hinterland Hospital and Health Service, Cairns, QLD, Australia.

College of Medicine and Dentistry, James Cook University, Cairns, QLD, Australia.

College of Medicine and Dentistry, James Cook University, Cairns, QLD, Australia.

Queensland Health, Cairns and Hinterland Hospital and Health Service, Cairns, QLD, Australia.

Australian Institute of Tropical Health and Medicine, College of Public Health, Medical and Veterinary Sciences, James Cook University, Cairns, QLD, Australia.

School of Health Sciences, University of South Australia, Adelaide, SA, Australia.

Front Dement . 2023 Jul 31:2:1218709. doi: 10.3389/frdem.2023.1218709. eCollection 2023.

2813-3919

https://pubmed.ncbi.nlm.nih.gov/39081976/?otool=iaurydwlib

https://hdl.handle.net/10137/13498

Australia

First Nations

Indigenous

dementia

prevention

Primary care biomarkers and dementia in people of the Torres Strait, Australia: extended data analysis.

Journal Article

Publication