Howarth, Timothy

Heraganahally, Subash

White, Elisa

Sorger, Lisa

Biancardi, Edwina

Ben Saad, Helmi

2020-11-09

Background: There is sparse literature evidence evaluating the applicability of the GLI-2012 spirometric norms for Australian Aboriginal adults. Methods: Lung function parameters (LFPs) were compared between Australian Aboriginal and Australian Caucasians, and the fit of Australian Aboriginals LFPs with various ethnic GLI equations was tested. Results: Of 1350 and 5634 Pulmonary function tests (PFTs) in Australian Aboriginal and Australian Caucasian adults, 153 and 208 PFTs matched for anthropometrics and normal chest radiology, respectively. Absolute FVC and FEV(1) values were 20% lower in Australian Aboriginals compared to Australian Caucasians. Differences remained significant after accounting for age, sex, height, weight and smoking status in multivariate regression (FVC -0.84 L (-0.98, -0.71), FEV(1) -0.72 L (-0.84, -0.59), but with nearly preserved FEV(1)/FVC. GLI-2012 transformation resulted in z-scores significantly below zero for each of FVC, FEV(1) and FEV(1)/FVC with z-scores ranging from -4.52 (-4.87, -4.16) for North East Asian FVC transformation for males, to -0.34 (-0.73, 0.05) for Black FVC transformation for females. Conclusions: Australian Aboriginal adults had 20% lower values for FVCandFEV(1) but nearly preserved absolute FEV(1)/FVC in comparison to Australian Caucasians. The GLI-2012 spirometric norms do not appear to fit for Australian Aboriginal adults regardless of which ethnicity options selected, including "others/mixed".

Department of Respiratory and Sleep Medicine, Royal Darwin Hospital , Darwin, Northern Territory, Australia.

Flinders University - College of Medicine and Public Health , Adelaide, South Australia, Australia.

Darwin Respiratory and Sleep Health, Darwin Private Hospital , Darwin, Northern Territory,Australia.

College of Health and Human Sciences, Charles Darwin University , Darwin, Northern Territory, Australia.

Department of Medical Imaging, Royal Darwin Hospital , Darwin, Northern Territory, Australia.

Faculté de Médecine de Sousse, Laboratoire de Physiologie, Université de Sousse , Sousse, Tunisia.

Department of Physiology and Functional Exploration. Farhat HACHED Hospital of Sousse, Tunisia.

Heart Failure Research Laboratory(LR12SP09), Farhat HACHED Hospital , Sousse, Tunisia.

Expert Rev Respir Med . 2021 Jun;15(6):833-843. doi: 10.1080/17476348.2021.1847649. Epub 2020 Nov 23.

0000-0002-7477-2965

https://pubmed.ncbi.nlm.nih.gov/33166208/?otool=iaurydwlib

https://hdl.handle.net/10137/11483

Lung function parameters among Australian Aboriginal "Apparently Healthy" Adults: an Australian Caucasian and Global Lung Function Initiative (GLI-2012) various ethnic norms comparative study.

Journal Article

Publication