Balabanski, Anna H

Goldsmith, Kendall

Giarola, Blake

Buxton, David

Castle, Sally

McBride, Katharine

Brady, Stephen

Thrift, Amanda G

Katzenellenbogen, Judith

Brown, Alex

Burrow, James

Donnan, Geoffrey A

Koblar, Simon

Kleinig, Timothy J

2020-10-08

OBJECTIVES: We aimed to compare the incidence, subtypes and aetiology of stroke, and in-hospital death due to stroke, between Aboriginal and non-Aboriginal people in Central Australia, a remote region of Australia where a high proportion Aboriginal people reside (40% of the population). We hypothesised that the rates of stroke, particularly in younger adults, would be greater in the Aboriginal population, compared with the non-Aboriginal population; we aimed to elucidate causes for any identified disparities. DESIGN: A retrospective population-based study of patients hospitalised with stroke within a defined region from 1 January 2011 to 31 December 2014. SETTING: Alice Springs Hospital, the only neuroimaging-capable acute hospital in Central Australia, serving a network of 50 healthcare facilities covering 672 000 km(2). PARTICIPANTS: 161 residents (63.4% Aboriginal) of the catchment area admitted to hospital with stroke. PRIMARY AND SECONDARY OUTCOME MEASURES: Rates of first-ever stroke, overall (all events) stroke and in-hospital death. RESULTS: Of 121 residents with first-ever stroke, 61% identified as Aboriginal. Median onset-age (54 years) was 17 years younger in Aboriginal patients (p<0.001), and age-standardised stroke incidence was threefold that of non-Aboriginal patients (153 vs 51 per 100 000, incidence rate ratio 3.0, 95% CI 2 to 4). The rate ratios for the overall rate of stroke (first-ever and recurrent) were similar. In Aboriginal patients aged <55 years, the incidence of ischaemic stroke was 14-fold greater (95% CI 4 to 45), and intracerebral haemorrhage 19-fold greater (95% CI 3 to 142) than in non-Aboriginal patients. Crude prevalence of diabetes mellitus (70.3% vs 34.0%, p<0.001) and hypercholesterolaemia (68.9% vs 51.1%, p=0.049) was greater, and age-standardised in-hospital deaths were fivefold greater (35 vs 7 per 100 000, 95% CI 2 to 11) in Aboriginal patients than in non-Aboriginal patients. CONCLUSIONS: Stroke incidence (both subtypes) and in-hospital deaths for remote Aboriginal Australians are dramatically greater than in non-Aboriginal people, especially in patients aged <55 years.

Department of Neurology, Royal Adelaide Hospital, Adelaide, South Australia, Australia.

Department of Medicine, School of Clinical Sciences, Monash University, Clayton, Victoria, Australia.

Department of Neurology, Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia.

Aboriginal Research Unit, South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia.

Department of Medicine, Alice Springs Hospital, Alice Springs, Northern Territory, Australia.

School of Population and Global Health, The University of Western Australia, Perth, Western Australia, Australia.

Adelaide Medical School, Faculty of Health and Medical Sciences, The University of Adelaide, Adelaide, South Australia, Australia.

Department of Neurology, Royal Darwin Hospital, Casuarina, Northern Territory, Australia.

Department of Medicine and Neurology, Melbourne Brain Centre at Royal Melbourne Hospital, Parkville, Victoria, Australia.

Stroke Research Programme, The University of Adelaide, Adelaide, South Australia, Australia.

Department of Neurology, Royal Adelaide Hospital, Adelaide, South Australia, Australia timothy.kleinig@sa.gov.au.

BMJ Open. 2020 Oct 8;10(10):e039533. doi: 10.1136/bmjopen-2020-039533.

0000-0003-3209-3101

0000-0001-8533-4170

0000-0001-5287-5819

https://pubmed.ncbi.nlm.nih.gov/33033097/?otool=iaurydwlib

https://hdl.handle.net/10137/11435

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Stroke incidence and subtypes in Aboriginal people in remote Australia: a healthcare network population-based study.

Journal Article

Publication