Damelang, Timon

Aitken, Elizabeth H

Hasang, Wina

Lopez, Ester

Killian, Martin

Unger, Holger W

Salanti, Ali

Shub, Alexis

McCarthy, Elizabeth

Kedzierska, Katherine

Lappas, Martha

Kent, Stephen J

Rogerson, Stephen J

Chung, Amy W

2021-02-18

Immune effector responses against Plasmodium falciparum include antibody-mediated activation of innate immune cells, which can induce Fc effector functions, including antibody-dependent cellular cytotoxicity, and the secretion of cytokines and chemokines. These effector functions are regulated by the composition of immunoglobulin G (IgG) Fc N-linked glycans. However, a role for antibody-mediated natural killer (NK) cells activation or Fc N-linked glycans in pregnant women with malaria has not yet been established. Herein, we studied the capacity of IgG antibodies from pregnant women, with placental malaria or non-placental malaria, to induce NK cell activation in response to placental malaria-associated antigens DBL2 and DBL3. Antibody-mediated NK cell activation was observed in pregnant women with malaria, but no differences were associated with susceptibility to placental malaria. Elevated anti-inflammatory glycosylation patterns of IgG antibodies were observed in pregnant women with or without malaria infection, which were not seen in healthy non-pregnant controls. This suggests that pregnancy-associated anti-inflammatory Fc N-linked glycans may dampen the antibody-mediated activation of NK cells in pregnant women with malaria infection. Overall, although anti-inflammatory glycans and antibody-dependent NK cell activation were detected in pregnant women with malaria, a definitive role for these antibody features in protecting against placental malaria remains to be proven.

Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, VIC, Australia.

Department of Medicine, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, VIC, Australia.

Department of Internal Medicine, Centre Hospitalier Universitaire de Saint-Etienne, Saint-Etienne, France.

Groupe sur l'Immunité des Muqueuses et Agents Pathogènes, Université Jean Monnet Saint-Etienne, Saint-Etienne, France.

Liverpool School of Tropical Medicine, Liverpool, UK.

Department of Obstetrics and Gynaecology, Royal Darwin Hospital, Darwin, NT, Australia.

Menzies School of Health Research, Charles Darwin University, Darwin, NT, Australia.

Department for Immunology and Microbiology, Centre for Medical Parasitology, University of Copenhagen, Copenhagen, Denmark.

Department of Infectious Disease, Copenhagen University Hospital, Copenhagen, Denmark.

Department of Obstetrics and Gynaecology, University of Melbourne, Melbourne, VIC, Australia.

Infectious Diseases Department, Alfred Health, Melbourne Sexual Health Centre, Monash University, Melbourne, VIC, Australia.

Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, VIC, Australia. awchung@unimelb.edu.au.

Sci Rep. 2021 Feb 18;11(1):4130. doi: 10.1038/s41598-021-83093-4.

https://pubmed.ncbi.nlm.nih.gov/33602987/?otool=iaurydwlib

https://hdl.handle.net/10137/11670

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Antibody mediated activation of natural killer cells in malaria exposed pregnant women.

Journal Article

Publication