Titmuss, Angela

Longmore DK

Barzi F

Barr, ELM

Webster V

Wood, Anna

Simmonds A

Brown ADH

Connors, Christine

Boyle JA

Oats J

McIntyre HD

Shaw JE

Craig ME

Maple-Brown, Louise

2022-05-29

BACKGROUND: Few studies have assessed whether children exposed to in utero hyperglycaemia experience different growth trajectories compared to unexposed children. OBJECTIVES: To assess association of type 2 diabetes (T2D) and gestational diabetes mellitus (GDM) with early childhood weight, length/height and body mass index (BMI) trajectories, and with timing and magnitude of peak BMI in infancy. METHODS: PANDORA is a birth cohort recruited from an Australian hyperglycaemia in pregnancy register, and women with normoglycaemia recruited from the community. Offspring growth measures were obtained from health records over a median follow-up of 3.0 years (interquartile range 1.9-4.0). This analysis included children born to Aboriginal mothers with in utero normoglycaemia (n = 95), GDM (n = 228) or T2D (n = 131). Growth trajectories (weight, length/height and BMI) were estimated using linear mixed models with cubic spline functions of child age. RESULTS: After adjustment for maternal factors (age, BMI, parity, smoking, and socioeconomic measures) and child factors (age, gestational age at birth, and sex), children born to mothers with T2D or GDM had lower weight, length/height and BMI trajectories in infancy than children born to mothers with normoglycaemia, but similar weight and BMI by completion of follow-up. Children exposed to T2D had lower mean peak BMI 17.6 kg/m(2) (95% confidence interval [CI] 17.3-18.0) than children exposed to normoglycaemia (18.6 kg/m(2) [18.1-18.9]) (p = 0.001). CONCLUSIONS: Maternal hyperglycaemia was associated with differences in early childhood growth trajectories after adjustment for maternal BMI. Exploration of associations between in utero hyperglycaemia exposure and growth trajectories into later childhood is required.

Wellbeing and Preventable Chronic Diseases Division, Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia.

Department of Paediatrics, Division of Women, Children and Youth, Royal Darwin Hospital, Darwin, Northern Territory, Australia.

Poche Centre for Indigenous Health, University of Queensland, Brisbane, Queensland, Australia.

Clinical and Population Health, Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia.

Endocrinology Department, Division of Medicine, Royal Darwin Hospital, Darwin, Northern Territory, Australia.

Wardliparingga Aboriginal Research Unit, South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia.

Faculty of Health and Medical Science, University of Adelaide, Adelaide, South Australia, Australia.

Top End Health Service, Northern Territory Department of Health, Darwin, Northern Territory, Australia.

Monash Centre for Health Research and Implementation, School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.

Melbourne School of Population and Global Health, University of Melbourne, Melbourne, Victoria, Australia.

Faculty of Medicine, Mater Medical Research Institute, University of Queensland, Brisbane, Queensland, Australia.

School of Women and Children's Health, University of New South Wales, Sydney, New South Wales, Australia.

BMJ Open . 2020 Jan 2;10(1):e030034. doi: 10.1136/bmjopen-2019-030034.

0000-0002-9865-1252

0000-0002-6232-8947

https://pubmed.ncbi.nlm.nih.gov/35644889/?otool=iaurydwlib

https://hdl.handle.net/10137/12188

Association between hyperglycaemia in pregnancy and growth of offspring in early childhood: The PANDORA study.

Journal Article

Publication