Yeo TW; Lampah DA; Kenangalem E; Tjitra E; Weinberg JB; Granger DL; Price, Richard; Anstey, Nicholas

Decreased endothelial nitric oxide bioavailability, impaired microvascular function, and increased tissue oxygen consumption in children with falciparum malaria.

Author(s)

Yeo TW

Lampah DA

Kenangalem E

Tjitra E

Weinberg JB

Granger DL

Price, Richard

Anstey, Nicholas

Publication Date

2014-11-15

Abstract

Endothelial nitric oxide (NO) bioavailability, microvascular function, and host oxygen consumption have not been assessed in pediatric malaria. We measured NO-dependent endothelial function by using peripheral artery tonometry to determine the reactive hyperemia index (RHI), and microvascular function and oxygen consumption (VO2) using near infrared resonance spectroscopy in 13 Indonesian children with severe falciparum malaria and 15 with moderately severe falciparum malaria. Compared with 19 controls, children with severe malaria and those with moderately severe malaria had lower RHIs (P = .03); 12% and 8% lower microvascular function, respectively (P = .03); and 29% and 25% higher VO2, respectively. RHIs correlated with microvascular function in all children with malaria (P < .001) and all with severe malaria (P < .001). Children with malaria have decreased endothelial and microvascular function and increased oxygen consumption, likely contributing to the pathogenesis of the disease.

Citation

J Infect Dis . 2014 Nov 15;210(10):1627-32. doi: 10.1093/infdis/jiu308. Epub 2014 May 30.

Pubmed ID

https://pubmed.ncbi.nlm.nih.gov/24879801/?otool=iaurydwlib

Link

https://hdl.handle.net/10137/5589

Subject

Plasmodium falciparum

cerebral malaria

endothelial function

microvascular function

oxygen consumption

severe malaria

tissue hypoxia

MESH subject

Animals

Child

Child, Preschool

Endothelial Cells

Female

Humans

Malaria, Falciparum

Male

Microvessels

Nitric Oxide

Spectroscopy, Near-Infrared

Oxygen Consumption

Title

Decreased endothelial nitric oxide bioavailability, impaired microvascular function, and increased tissue oxygen consumption in children with falciparum malaria.

Type of document

Journal Article

Entity Type

Publication

Author(s)	Yeo TW Lampah DA Kenangalem E Tjitra E Weinberg JB Granger DL Price, Richard Anstey, Nicholas
Publication Date	2014-11-15
Abstract	Endothelial nitric oxide (NO) bioavailability, microvascular function, and host oxygen consumption have not been assessed in pediatric malaria. We measured NO-dependent endothelial function by using peripheral artery tonometry to determine the reactive hyperemia index (RHI), and microvascular function and oxygen consumption (VO2) using near infrared resonance spectroscopy in 13 Indonesian children with severe falciparum malaria and 15 with moderately severe falciparum malaria. Compared with 19 controls, children with severe malaria and those with moderately severe malaria had lower RHIs (P = .03); 12% and 8% lower microvascular function, respectively (P = .03); and 29% and 25% higher VO2, respectively. RHIs correlated with microvascular function in all children with malaria (P < .001) and all with severe malaria (P < .001). Children with malaria have decreased endothelial and microvascular function and increased oxygen consumption, likely contributing to the pathogenesis of the disease.
Citation	J Infect Dis . 2014 Nov 15;210(10):1627-32. doi: 10.1093/infdis/jiu308. Epub 2014 May 30.
Pubmed ID	https://pubmed.ncbi.nlm.nih.gov/24879801/?otool=iaurydwlib
Link	https://hdl.handle.net/10137/5589
Subject	Plasmodium falciparum cerebral malaria endothelial function microvascular function oxygen consumption severe malaria tissue hypoxia
MESH subject	Animals Child Child, Preschool Endothelial Cells Female Humans Malaria, Falciparum Male Microvessels Nitric Oxide Spectroscopy, Near-Infrared Oxygen Consumption
Title	Decreased endothelial nitric oxide bioavailability, impaired microvascular function, and increased tissue oxygen consumption in children with falciparum malaria.
Type of document	Journal Article
Entity Type	Publication

Decreased endothelial nitric oxide bioavailability, impaired microvascular function, and increased tissue oxygen consumption in children with falciparum malaria.

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