Longmore DK

Barr ELM

Lee I-L

Barzi F

Kirkwood M

Whitbread C

Hampton V

Graham S

Van Dokkum P

Connors C

Boyle JA

Catalano P

Brown ADH

O'Dea K

Oats J

McIntyre HD

Shaw JE

Maple-Brown LJ

2019-01-16

In-utero exposures likely influence the onset and severity of obesity in youth. With increasing rates of type 2 diabetes mellitus (T2DM) and maternal adiposity in pregnancy globally, it is important to assess the impact of these factors on neonatal adipose measures. To evaluate the contribution of maternal ethnicity, body mass index (BMI), gestational weight gain, and hyperglycaemia to neonatal adiposity. Pregnancy and Neonatal Diabetes Outcomes in Remote Australia (PANDORA) is a longitudinal cohort study of Australian mother and neonate pairs. In this analysis, Indigenous (n = 519) and Europid (n = 358) women were included, of whom 644 had hyperglycaemia (type 2 diabetes [T2DM], diabetes in pregnancy [DIP], or gestational diabetes [GDM]). Associations between maternal ethnicity, hyperglycaemia, BMI and gestational weight gain, and the neonatal outcomes of length, head circumference, sum of skinfolds, total body fat, and percentage body fat were examined. Models were adjusted for maternal age, smoking status, parity, education, neonatal gender, and gestational age. Among those with hyperglycaemia in pregnancy, Indigenous women had a higher proportion of T2DM and DIP (36%, 13%) compared with Europid women (4%, 3%). In multivariate analysis, maternal T2DM (compared with no hyperglycaemia), BMI during pregnancy, and excess compared with appropriate gestational weight gain, were significantly associated with greater neonatal measures. DIP was associated with greater sum of skinfolds, total body fat, and percentage body fat. Indigenous ethnicity was associated with greater sum of skinfolds. Maternal BMI, excess gestational weight gain, and hyperglycaemia operated as independent factors influencing neonatal adiposity. Interventions addressing these factors are needed to reduce neonatal adiposity.

Wellbeing and Preventable Chronic Diseases Division, Menzies School of Health Research, Darwin, Australia.. Department of Paediatrics, Western Health, Melbourne, Australia..

Wellbeing and Preventable Chronic Diseases Division, Menzies School of Health Research, Darwin, Australia.. Baker Heart and Diabetes Institute, Melbourne, Australia..

Wellbeing and Preventable Chronic Diseases Division, Menzies School of Health Research, Darwin, Australia..

Wellbeing and Preventable Chronic Diseases Division, Menzies School of Health Research, Darwin, Australia..

Wellbeing and Preventable Chronic Diseases Division, Menzies School of Health Research, Darwin, Australia..

Wellbeing and Preventable Chronic Diseases Division, Menzies School of Health Research, Darwin, Australia.. Division of Medicine, Royal Darwin Hospital, Darwin, Australia..

Wellbeing and Preventable Chronic Diseases Division, Menzies School of Health Research, Darwin, Australia..

Wellbeing and Preventable Chronic Diseases Division, Menzies School of Health Research, Darwin, Australia..

Wellbeing and Preventable Chronic Diseases Division, Menzies School of Health Research, Darwin, Australia.. Baker Heart and Diabetes Institute, Alice Springs, Australia..

Northern Territory Department of Health, Darwin, Australia..

Monash Centre for Health Research and Implementation, School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia..

Tufts University School of Medicine, Boston, Massachusetts..

South Australian Health and Medical Research Institute, Adelaide, Australia..

Wellbeing and Preventable Chronic Diseases Division, Menzies School of Health Research, Darwin, Australia..

Melbourne School of Population and Global Health, University of Melbourne, Melbourne, Australia..

Mater Medical Research Institute, University of Queensland, Brisbane, Australia..

Baker Heart and Diabetes Institute, Melbourne, Australia..

Wellbeing and Preventable Chronic Diseases Division, Menzies School of Health Research, Darwin, Australia.. Division of Medicine, Royal Darwin Hospital, Darwin, Australia..

Pediatric obesity 2019-01-16: e12490

0000-0002-6232-8947

0000-0003-4284-1716

https://pubmed.ncbi.nlm.nih.gov/30650263/?otool=iaurydwlib

https://hdl.handle.net/10137/7337

adiposity

diabetes

indigenous

neonatal

Maternal body mass index, excess gestational weight gain, and diabetes are positively associated with neonatal adiposity in the Pregnancy and Neonatal Diabetes Outcomes in Remote Australia (PANDORA) study.

Journal Article

Publication