Howarth, Timothy

Gibbs, Claire

Abeyaratne, Asanga

Heraganahally, Subash

2024-12-04

The prevalence of bronchiectasis is significantly higher among adult Aboriginal Australians (the Indigenous peoples of Australia) compared to non-Aboriginal Australians. Currently, there is no well-established tool to assess bronchiectasis severity specific to Indigenous peoples. Nor has the applicability and validity of the two well-established bronchiectasis severity assessment tools - The "Bronchiectasis Severity Index" (BSI) and "FACED" scale been vigorously tested in an Indigenous population. This retrospective study evaluated the validity of the BSI and FACED amongst an adult Aboriginal Australian cohort with bronchiectasis in the Top End Northern Territory (NT) of Australia.Patients with CT confirmed bronchiectasis identified between 2011 and 2020, residing in the Top End of the NT were eligible to be enrolled. The primary endpoint of 4-year mortality was assessed via hospital records, and sensitivity and specificity of the BSI and FACED assessed against this using area under the curve (AUC) receiver operating characteristics analysis. For patients with missing data, a relative BSI / FACED score was used which divided the score recorded for that patient by the total potential score based on their available clinical data.A total of 456 adult Aboriginal Australian patients >18 years of age were included (55.5% female, median age 49 years). According to the BSI score 43.4% of patients were assessed to have mild, 30.5% moderate and 26.1% severe bronchiectasis (median score 4 (IQR 2, 8)). According to the FACED 80.9% were assessed to have mild, 17.8% moderate and 1.3% severe (median score of 1 (IQR 0, 2)). Four-year mortality was 11.2% (median age of death 55.6 years). Sensitivity and specificity of the BSI combining moderate and severe were 86.3 and 47.2% respectively, and for severe alone 51% and 77%. Sensitivity and specificity of the FACED combining moderate and severe were 21.6% and 81.2%, respectively, and for severe alone 2% and 98.8%. The AUC for the continuous total BSI was 0.703, and the FACED 0.515. Utilising a relative score, based only on data available for patients with missing data (ie lung function or BMI) resulted in slightly improved AUCs for both the BSI (0.717) and FACED (0.571).Both BSI and FACED bronchiectasis assessment tools may not be ideal in an Indigenous/Aboriginal people's context. However, it may be reasonable to utilise the relative BSI score in this population until Indigenous people's specific bronchiectasis severity assessment tools are developed.Adult Indigenous people globally have a higher prevalence of chronic respiratory disorders, and bronchiectasis is no exception. To assess the bronchiectasis severity and to predict future mortality, there are well-established assessment tools. However, the existing bronchiectasis assessment tools are developed predominately from data gathered from non-Indigenous population cohorts. To date, it is unclear if these existing bronchiectasis assessment tools are appropriate or applicable for Indigenous people. Therefore, this study assessed how existing bronchiectasis tools, namely the “Bronchiectasis Severity Index” (BSI) and “FACED” [Forced expiratory volume in 1 s, Age, Chronic colonization, Extension, and Dyspnea] fit for an adult Indigenous/ Aboriginal Australian cohort diagnosed to have bronchiectasis. The results of the study showed that both BSI and FACED assessment tools may not be ideal in the Australian Indigenous/Aboriginal population, due to population demographics and other social determinants, including geographical isolation. Hence, further research is warranted in developing Indigenous/Aboriginal specific bronchiectasis assessment tools.

Darwin Respiratory and Sleep Health, Darwin Private Hospital, Darwin, NT, Australia.

Department of Technical Physics, University of Eastern Finland, Kuopio, North Savo, Finland.

Department of Respiratory and Sleep Medicine, Royal Darwin Hospital, Darwin, NT, Australia.

Menzies School of Health Research, Darwin, Northern Territory, Australia.

Darwin Respiratory and Sleep Health, Darwin Private Hospital, Darwin, NT, Australia.

Department of Respiratory and Sleep Medicine, Royal Darwin Hospital, Darwin, NT, Australia.

Flinders University, College of Medicine and Public Health, Darwin, NT, Australia.

School of Medicine, Charles Darwin University, Darwin, NT, Australia.

Int J Chron Obstruct Pulmon Dis . 2024 Dec 4:19:2611-2628. doi: 10.2147/COPD.S482848. eCollection 2024.

1178-2005

https://pubmed.ncbi.nlm.nih.gov/39650744/?otool=iaurydwlib

https://hdl.handle.net/10137/13872

assessment

hospital admissions

scale

severity

spirometry

tool

Adult

Aged

Female

Humans

Male

Middle Aged

Australian Aboriginal and Torres Strait Islander Peoples

Bronchiectasis

Lung

Northern Territory

Predictive Value of Tests

Prevalence

Prognosis

Reproducibility of Results

Retrospective Studies

Severity of Illness Index

Time Factors

Tomography, X-Ray Computed

Applicability and Validity of the "Bronchiectasis Severity Index" (BSI) and "FACED" Score in Adult Aboriginal Australians.

Journal Article

Publication