This is a cohort study of patients with moderate to severe traumatic brain injury, across hospitals in Queensland, the NT and NSW. Using novel blood biomarkers and novel MRI imaging protocols we aim to predict the functional outcome of moderate to severe TBI in ICU survivors. The multiple predictors are being assessed using best practice in supervised learning, with a very high chance of detecting real effects and a very low chance of adopting practices which are of low yield. Among the biomarkers are many which are being assessed for the first time, which is made possible using a new assay procedure developed by CSIRO. There are few prospective cohorts in TBI in Australia, and none with the depth of clinical information brought by this project. It will involve MRI scans above normal care. All costs to the patient for these will be covered, with travel arranged under the study. Support in principle has been obtained from the Director of Radiology. Support from the Pathology department has also been obtained in principle for preparation, storage and sending of blood samples, with negotiations on precise costs ongoing, to which the RGO has been party