Patients presenting to Emergency Department (ED) with shock caused by infection (septic shock) as a part of standard care receive resusdtation with intravenous fluids and/or vasopressors (medication to raise the blood pressure). This study is a randomised, clinical trial of a restricted intravenous fluids and early vasopressor strategy compared to a larger initial intravenous fluid volume and later vasopressors for patients with septic shock. We hypothesise that a restricted fluids volume and early vasopressors approach, compared to a larger initial fluid volume and later introduction of vasopressors approach to restore blood pressure, will increase the number of days alive and out of hospital at day 90 in patients presenting to the ED with early septic shock. The allocated fluid/vasopressor strategy will be followed for 6-24 hours.

https://hdl.handle.net/10137/12740

Septic shock

Australian Resuscitation in Sepsis Evaluation: Fluid or vasopressors in Emergency Department Sepsis

Interventional/Clinical trials research

Project