Research and Conference Publications

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This collection contains journal articles and other research publications such as book chapters, conference papers, and posters authored by NT Health staff and provides an overview of the interests, research activities and projects undertaken by NT Health staff. Most journal articles are published in subscription-based or open access publications, so this collection contains mainly citations and links to full text content on external sites, but where permitted, the PDF file has been made available.

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Recent Submissions

Now showing 1 - 5 of 2013
  • Publication
    Melioidosis and the liver
    (Elsevier Inc., 2025)
    None available.
  • Publication
    63 - Scabies
    (Elsevier Limited, 2023-10-13) ;
    McCarthy, James S.
    Scabies presents as an intensely pruritic rash that predominantly involves hairless and thin skin such as web spaces of the hands and skin creases. Sensitization to mite products is responsible for the itch and therefore symptom onset is usually delayed by weeks in the first infection. Secondary bacterial infection with Staphylococcus aureus and Streptococcus pyogenes is responsible for significant morbidity. Crusted scabies, the most severe form of scabies, presents as a hyperkeratotic rash. Lesions are loaded with mites and such patients are highly infectious. Direct skin-to-skin contact is the most important mode of transmission. Parasitological diagnosis is difficult and therefore clinical diagnosis is usually relied upon, although new diagnostic methods are under development. The most commonly used treatment of choice is topical permethrin cream applied to the whole body. Ivermectin, administered orally, is increasingly being used, including for mass drug administration.
  • Publication
    94: Of Microbes and Mud
    (Febrile, 2024-03-04)
    Dong, Sara
    ;
    ; ;
    “Drs. Genevieve Martin, Catherine Marshall, and Bart Currie from the Royal Darwin Hospital share their approach to Burkholderia pseudomallei aka melioidosis!”
  • Publication
    Aboriginal and Torres Strait Islander, New Zealand Māori and Remote Area Mental Health
    (Oxford University Press, 2018)
    Tinning, Verena
    ;
    Thompson, Graeme
    "This chapter is divided into three sections. The first provides the reader with a historical perspective of Australian Aboriginal and Torres Strait islander peoples, the impact of colonisation and contemporary access to mental health care. The second section is written from a remote rural mental health nurse perspective, providing insight into some of the concerns and challenges of working in often far distant places, away from acute care services, to provide mental health care to Indigenous people within Australia. The last section comes from our colleagues in New Zealand, exploring the bi-cultural nature of mental health care in that country. This section offers insights into how care can be provided within a culturally safe and inclusive manner. " -- taken from the introduction to the chapter.
  • Publication
    Global gene expression profile of proliferative verrucous leukoplakia and its underlying biological disease mechanisms.
    (2024)
    Farah, Camile S
    ;
    Shearston, Kate
    ;
    Turner, Emma C
    ;
    Vacher, Michael
    ;
    Fox, Simon A
    BACKGROUND: Proliferative verrucous leukoplakia (PVL) is a rare and enigmatic oral potentially malignant disorder which almost invariably results in oral squamous cell carcinoma (OSCC). The aims of this project were to use transcriptome profiling to characterise PVL gene expression patterns for biomarker identification and gain insight into the molecular aetiopathogenesis of PVL. METHODS: Forty-three oral cavity mucosal biopsies from 32 patients with oral lesions clinically compatible with either PVL or non-PVL conventional oral leukoplakia (OLK) underwent transcriptome profiling by RNA sequencing. Data was analysed by hierarchical clustering, differential gene expression, functional enrichment and network analysis, sparse partial least squares discriminant analysis sPLS-DA, and immune cell phenotypic estimation. RESULTS: We found 464 genes significantly differentially expressed at least 2-fold between PVL and non-PVL OLK (193 up and 271 down). HOX genes, including HOXA1 and HOXB7, keratin-associated proteins (KRTAPs) and olfactory receptor G proteins (OR) were significantly upregulated in PVL. Other upregulated genes in PVL included FOS, WNT16 and IFNA1. Pathway analysis showed that there was a significant downregulation of connective tissue signalling in PVL. Classifying multivariate models based upon 22 genes discriminated PVL from non-PVL OLK. Bioinformatic profiling showed that immune cell profiles in PVL and OLK were similar except that fibroblast markers were reduced in PVL. CONCLUSION: These results demonstrate that PVL and conventional OLK are molecularly distinct with upregulation of many cancer-associated genes. They provide insight into the pathogenesis of PVL and show that biomarker based molecular diagnostics is feasible to discriminate and inform diagnosis and management.