Please use this identifier to cite or link to this item: https://hdl.handle.net/10137/2672
Title: Whole genome sequencing to investigate a putative outbreak of the virulent community-associated methicillin-resistant Staphylococcus aureus ST93 clone in a remote Indigenous community.
Publication Date: 2016-12
Authors: Meumann, Ella M
Andersson, Patiyan
Yeaman, Fiona
Oldfield, Sarah
Lilliebridge, Rachael
Bentley, Stephen D
Krause, Vicki
Beaman, Miles
Currie, Bart J
Holt, Deborah C
Giffard, Philip M
Tong, Steven Y C
Affiliation: Global and Tropical Health Division, Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia; Department of Infectious Diseases, Royal Darwin Hospital, Darwin, Northern Territory, Australia; Centre for Disease Control, Department of Health, Northern Territory Government, Darwin, Northern Territory, Australia..
Global and Tropical Health Division, Menzies School of Health Research, Charles Darwin University , Darwin, Northern Territory , Australia..
Department of Infectious Diseases, Royal Darwin Hospital, Darwin, Northern Territory, Australia..
Department of Infectious Diseases, Royal Darwin Hospital, Darwin, Northern Territory, Australia..
Global and Tropical Health Division, Menzies School of Health Research, Charles Darwin University , Darwin, Northern Territory , Australia..
Wellcome Trust Sanger Institute , Hinxton, Cambridge , UK..
Centre for Disease Control, Department of Health, Northern Territory Government , Darwin, Northern Territory , Australia..
School of Pathology and Laboratory Medicine, University of Western Australia , Perth, Western Australia , Australia..
Global and Tropical Health Division, Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia; Department of Infectious Diseases, Royal Darwin Hospital, Darwin, Northern Territory, Australia..
Global and Tropical Health Division, Menzies School of Health Research, Charles Darwin University , Darwin, Northern Territory , Australia..
Global and Tropical Health Division, Menzies School of Health Research, Charles Darwin University , Darwin, Northern Territory , Australia..
Global and Tropical Health Division, Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia; Department of Infectious Diseases, Royal Darwin Hospital, Darwin, Northern Territory, Australia..
Publication Date: Dec-2016
Abstract: We report two cases of severe pneumonia due to clone ST93 methicillin-resistant Staphylococcus aureus (MRSA) presenting from a remote Australian Indigenous community within a 2-week period, and the utilization of whole genome sequences to determine whether these were part of an outbreak. S. aureus was isolated from 12 of 92 nasal swabs collected from 25 community households (including the two index households); one isolate was ST93. Three of five skin lesion S. aureus isolates obtained at the community were ST93. Whole genome sequencing of the ST93 isolates from this study and a further 20 ST93 isolates from the same region suggested that recent transmission and progression to disease had not taken place. The proximity in time and space of the two severe pneumonia cases is probably a reflection of the high burden of disease due to ST93 MRSA in this population where skin infections and household crowding are common.
Journal title: Microbial genomics
Citation: Microbial genomics 2016-12; 2(12): e000098
URI: https://hdl.handle.net/10137/2672
DOI: 10.1099/mgen.0.000098
PubMed: 28348837
ISSN: 2057-5858
Type: Journal Article
Subject: MRSA outbreak Indigenous whole genome sequencing
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